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Titolo:
DOPAMINE FUNCTION IN OBSESSIVE-COMPULSIVE DISORDER - GROWTH-HORMONE RESPONSE TO APOMORPHINE STIMULATION
Autore:
BRAMBILLA F; BELLODI L; PERNA G; ARANCIO C; BERTANI A;
Indirizzi:
IST SCI OSPED S RAFFAELE,DIPARTIMENTO SCI NEUROPSICHICHE,CTR PSICONEUROENDOCRINOL I-20129 MILAN ITALY IST SCI OSPED S RAFFAELE,DIPARTIMENTO SCI NEUROPSICHICHE,ANXIETY DISORDERS CLIN & RES UNIT I-20129 MILAN ITALY
Titolo Testata:
Biological psychiatry
fascicolo: 10, volume: 42, anno: 1997,
pagine: 889 - 897
SICI:
0006-3223(1997)42:10<889:DFIOD->2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
LA-TOURETTES SYNDROME; CEREBROSPINAL-FLUID NEUROCHEMISTRY; MEDIATED BEHAVIOR; ANIMAL-MODEL; GH SECRETION; GILLES; SCHIZOPHRENIA; AMPHETAMINE; ESTRADIOL; SEROTONIN;
Keywords:
OBSESSIVE-COMPULSIVE DISORDER; GROWTH HORMONE-RELEASING HORMONE TEST; APOMORPHINE TEST; GROWTH HORMONE; PROLACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
F. Brambilla et al., "DOPAMINE FUNCTION IN OBSESSIVE-COMPULSIVE DISORDER - GROWTH-HORMONE RESPONSE TO APOMORPHINE STIMULATION", Biological psychiatry, 42(10), 1997, pp. 889-897

Abstract

Indirect observations suggest that the dopaminergic system may be involved in the pathophysiology of obsessive-compulsive disorder (OCD). The dopaminergic function of 15 patients with OCD and 15 age/sex-matched controls was evaluated by measuring the growth hormone (GH) responses to stimulation with the dopaminergic agonist apomorphine (APO), which increases growth hormone-releasing hormone (GHRH), GH, and somatomedine C (SMD-C) secretions, Therefore, we measured basal plasma GH and SMD-C concentrations and GH responses to GHRH stimulation to exclude that a downstream pathology of the somatotropic axis could obscure the significance of the results of the APO rest. The response of prolactin (PRL) to APO inhibition were also measured. Basal plasma levels of GH,SMD-C, and PRL, GH responses to GHRH stimulation and PRL responses toAPO inhibition did not differ in the two groups of subjects. GH responses to APO stimulation were blunted in obsessive-compulsive (OC) patients. The emetic response to the same stimulation was stronger in patients than in controls. These responses suggest that in our OC patientsthere is a dysregulation of the dopaminergic system, which is possibly expressed in different ways in the various areas of the central nervous system. (C) 1997 Society of Biological Psychiatry.

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Documento generato il 03/06/20 alle ore 09:44:59