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Titolo:
URINARY IODINE EXCRETION DURING NORMAL-PREGNANCY IN HEALTHY WOMEN LIVING IN THE SOUTHWEST OF FRANCE - CORRELATION WITH MATERNAL THYROID PARAMETERS
Autore:
CARON P; HOFF M; BAZZI S; DUFOR A; FAURE G; GHANDOUR I; LAUZU P; LUCAS Y; MARAVAL D; MIGNOT F; RESSIGEAC P; VERTONGEN F; GRANGE V;
Indirizzi:
CHU RANGUEIL,SERV ENDOCRINOL & MALAD METAB,1 AVE J POULHES F-31054 TOULOUSE FRANCE CHU RANGUEIL,DEPT ENDOCRINOL F-31054 TOULOUSE FRANCE CHU RANGUEIL,DEPT NUCL MED F-31054 TOULOUSE FRANCE DEPT OBSTET & GYNECOL CASTRES MONTAUBAN FRANCE DEPT OBSTET & GYNECOL CASTRES RODEZ FRANCE DEPT OBSTET & GYNECOL CASTRES LAVAUR FRANCE DEPT OBSTET & GYNECOL CASTRES ST GAUDENS FRANCE DEPT OBSTET & GYNECOL CASTRES FOIX FRANCE DEPT OBSTET & GYNECOL CASTRES TOULOUSE FRANCE DEPT OBSTET & GYNECOL CASTRES ALBI FRANCE DEPT OBSTET & GYNECOL CASTRES CAHORS FRANCE UNIV BRUSSELS,DEPT CLIN CHEM BRUSSELS BELGIUM MERCK CLEVENOT LAB NOGENT SUR MARNE FRANCE
Titolo Testata:
Thyroid
fascicolo: 5, volume: 7, anno: 1997,
pagine: 749 - 754
SICI:
1050-7256(1997)7:5<749:UIEDNI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN CHORIONIC-GONADOTROPIN; SERUM FREE-THYROXINE; FREE TRIIODOTHYRONINE; BINDING GLOBULIN; ENDEMIC GOITER; DISORDERS; HORMONE; THYROGLOBULIN; CARCINOMA; TSH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
P. Caron et al., "URINARY IODINE EXCRETION DURING NORMAL-PREGNANCY IN HEALTHY WOMEN LIVING IN THE SOUTHWEST OF FRANCE - CORRELATION WITH MATERNAL THYROID PARAMETERS", Thyroid, 7(5), 1997, pp. 749-754

Abstract

A prospective study was undertaken to evaluate urinary iodine excretion and changes of maternal thyroid function during pregnancy in healthy women living in the southwest of France. The cohort included a totalof 347 pregnant women (mean age 28.0 +/- 0.5 years). Iodine concentration in a random urine sample and thyroid tests (free thyroxine [FT4],free triiodothyronine [FT3], thyrotropin (TSH), thyroxine-binding globulin [TBG], and thyroglobulin [Tg]) were measured at initial presentation (before 12 weeks of gestation), and during the ninth month of pregnancy. A thyroid ultrasound was performed 1 to 5 days after delivery in 246 mothers. Mean urinary iodine levels were low during the first trimester (6.9 +/- 0.4 mu g/dL), as well as during the ninth month of pregnancy (8.6 +/- 0.6 mu g/dL). During pregnancy, FT4 and T-3 concentrations decreased (p < .001), and TSH and Tg concentrations increased (p < .001). Thyroid hypertrophy (thyroid volume greater than 18 mL) waspresent in 15.4% of women whose first trimester urinary iodine concentration was less than 5 mu g/dL, but was present in only 3.5% of womenwhose urinary iodine concentration was greater than 10 mu g/dL. A goiter (thyroid volume greater than 22 mL) was present in 11% of the mothers. In conclusion, this prospective study shows that urinary iodine excretion is low in pregnant women living in the southwest of France. This low iodine intake is associated with reduced circulating thyroid hormone levels and growth of the thyroid gland. These data point to theneed of an increased iodine supply in these pregnant women to reduce the potential consequences of low iodine intake on maternal thyroid economy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:46:24