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Titolo:
MR-IMAGING OF HIGH-GRADE CEREBRAL GLIOMAS - VALUE OF DIFFUSION-WEIGHTED ECHOPLANAR PULSE SEQUENCES
Autore:
TIEN RD; FELSBERG GJ; FRIEDMAN H; BROWN M; MACFALL J;
Indirizzi:
DUKE UNIV,MED CTR,DEPT RADIOL,NEURORADIOL SECT,BOX 3808 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PEDIAT DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT NEUROL DURHAM NC 27710
Titolo Testata:
American journal of roentgenology
fascicolo: 3, volume: 162, anno: 1994,
pagine: 671 - 677
SICI:
0361-803X(1994)162:3<671:MOHCG->2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVOXEL INCOHERENT MOTION; PERFUSION; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.D. Tien et al., "MR-IMAGING OF HIGH-GRADE CEREBRAL GLIOMAS - VALUE OF DIFFUSION-WEIGHTED ECHOPLANAR PULSE SEQUENCES", American journal of roentgenology, 162(3), 1994, pp. 671-677

Abstract

OBJECTIVE. The purpose of this study was to evaluate the usefulness of diffusion-weighted echoplanar MR imaging in the examination of high-grade brain gliomas compared with that of conventional spin-echo (SE) or fast spin-echo (FSE) MR imaging. We hypothesize that diffusion-weighted MR imaging may enable us to differentiate various tumor components on the basis of differences in the diffusion of water. SUBJECTS AND METHODS. Conventional SE and FSE MR images were obtained in 10 patients with high-grade brain glioma. Diffusion-weighted echoplanar MR images were obtained with a head gradient coil capable of providing diffusion-weighted imaging along the cephalocaudal axis. Using SE and FSE MR images as a baseline, we evaluated the diffusion weighted MR images for usefulness in distinguishing tumor components on the basis of differences in diffusion. RESULTS. Areas of tumor that showed significant enhancement on T1-weighted SE MR images obtained after injection of contrast material were markedly hyperintense on diffusion-weighted images and had a lower apparent diffusion coefficient (ADC) than the ADCs fornonenhancing tumor and peritumoral edema. Cystic or necrotic portionsof tumor showed the most signal suppression on diffusion-weighted images and were associated with the highest ADCs. On TP-weighted FSE MR images, areas of hyperintensity observed in white matter oriented parallel to the direction of the diffusion gradient could be differentiatedinto two patterns on the basis of findings on diffusion-weighted images: areas that showed marked signal suppression with a higher ADC, most likely representing areas of predominantly peritumoral edema, and areas that showed a lesser degree of signal suppression with similar butslightly lower ADCs than those of edema, most likely representing areas of predominantly nonenhancing tumor. CONCLUSION. Diffusion-weightedechoplanar MR imaging is a useful technique for examining high-grade cerebral gliomas. It enabled us to differentiate various components ofthe tumor (e.g., enhancing, nonenhancing, cystic, or necrotic) and todistinguish areas of predominantly nonenhancing tumor from areas of predominantly peritumoral edema when the abnormality was located in thewhite matter aligned in the direction of the diffusion-weighted gradient. Diffusion-weighted echoplanar MR imaging appears to be a powerfultool in the characterization of brain neoplasms.

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Documento generato il 18/09/20 alle ore 16:56:31