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Titolo:
DEPENDENCE OF INDUCTION OF INTERPHASE DEATH OF CHINESE-HAMSTER OVARY CELLS EXPOSED TO ACCELERATED HEAVY-IONS ON LINEAR-ENERGY-TRANSFER
Autore:
SASAKI H; YATAGAI F; KANAI T; FURUSAWA Y; HANAOKA F; ZHU WG; MEHNATI P;
Indirizzi:
KYUSHU UNIV,FAC MED,DEPT EXPT RADIOL,HIGASHI KU,3-1-1 MAIDASHI FUKUOKA 81282 JAPAN INST PHYS & CHEM RES WAKO SAITAMA 351 JAPAN NATL INST RADIOL SCI CHIBA 263 JAPAN OSAKA UNIV,INST MOL & CELLULAR BIOL SUITA OSAKA 565 JAPAN
Titolo Testata:
Radiation research
fascicolo: 5, volume: 148, anno: 1997,
pagine: 449 - 454
SICI:
0033-7587(1997)148:5<449:DOIOID>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOMA CELLS; MAMMALIAN-CELLS; STRAND BREAKS; DNA; APOPTOSIS; IRRADIATION; RADIATION; BEAMS; INACTIVATION; DAMAGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
H. Sasaki et al., "DEPENDENCE OF INDUCTION OF INTERPHASE DEATH OF CHINESE-HAMSTER OVARY CELLS EXPOSED TO ACCELERATED HEAVY-IONS ON LINEAR-ENERGY-TRANSFER", Radiation research, 148(5), 1997, pp. 449-454

Abstract

Induction of interphase death was examined in Chinese hamster ovary cells exposed to accelerated heavy ions (carbon, neon, argon and iron) of various linear energy transfers (LETs) (10-2000 keV/mu m). The fraction of cells that underwent interphase death was determined by observing individual cells with time-lapse photography (direct method) as well as by counting cells undergoing interphase death made visible by the addition of caffeine (indirect method). After exposure to X rays, interphase death increased linearly with dose above a threshold of about10 Gy, whereas it increased at a higher rate without a threshold after exposure to high-LET heavy ions. The relative biological effectiveness (RBE) compared to X rays, as determined at the 50% level of induction, increased with LET, reached a maximum at an LET of approximately 230 keV/mu m and then decreased with further increase in LET. The rangeof LET values corresponding to the maximum RBE appears to be narrowerfor interphase death than for reproductive death (120-230 keV/mu m), as assayed using loss of colony-forming ability as a criterion. The inactivation cross section for interphase cell death reached a plateau of 5-10 mu m(2). This means that the probability for the induction of interphase death by traversal of a single heavy-ion track through the nucleus (size: about 130 mu m(2)) is about 0.04-0.08. (C) 1997 by Radiation Research Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 04:43:20