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Titolo:
DETECTION OF ANTIOXIDANT ENZYME-ACTIVITIES IN RENAL TISSUES OF EARLY-STAGE IGA NEPHROPATHY IN DDY MICE
Autore:
WANG LN; FUKUI M; SHOU I; YAGUCHI Y; FUNABIKI K; HORIKOSHI S; SHIRATO I; TOMINO Y;
Indirizzi:
JUNTENDO UNIV,SCH MED,DEPT MED,DIV NEPHROL,BUNKYO KU,2-1-1 HONGO TOKYO 113 JAPAN JUNTENDO UNIV,SCH MED,DEPT MED,DIV NEPHROL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Journal of clinical laboratory analysis
fascicolo: 6, volume: 10, anno: 1996,
pagine: 394 - 398
SICI:
0887-8013(1996)10:6<394:DOAEIR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANIMAL-MODEL;
Keywords:
ANTIOXIDANT ENZYME ACTIVITY; RENAL CORTEX; EARLY STAGE IGA NEPHROPATHY; DDY MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
L.N. Wang et al., "DETECTION OF ANTIOXIDANT ENZYME-ACTIVITIES IN RENAL TISSUES OF EARLY-STAGE IGA NEPHROPATHY IN DDY MICE", Journal of clinical laboratory analysis, 10(6), 1996, pp. 394-398

Abstract

The purpose of this study was to determine the antioxidant enzyme activities in renal tissues of early stage ddY mice, an animal model for primary IgA nephropathy. Eight- and 40-week-old ddY female mice and normal healthy Balb/c female mice were used in this study. The levels ofCu/Zn-SOD, Mn-SOD, and GSH-PX activities in the renal cortex were significantly higher in 40-week-old ddY mice than in Balb/c control mice of the same age; no change of catalase activity was observed. There were no significant differences in the levels of Cu/ZnSOD, Mn-SOD, GSH-PX, and catalase activities between the ddY mice and Balb/c mice at 8 weeks of age. Urinary protein was slightly higher in 40-week-old ddY mice. IgA or C3 was deposited at low levels in the glomerular mesangial areas of 8-week-old ddY mice. Marked depositions of IgA and C3 extended from the glomerular mesangial areas to the capillary walls of 40-week-old ddY mice. Expansion of glomerular mesangial matrices and mild mesangial cell proliferation was observed in 40-week-old ddY mice. Antioxidant enzyme activities in the renal cortex were already increased inthe early stage IgA nephropathy in 40-week-old ddY mice. These findings suggest that measurements of antioxidant enzyme activities in the renal cortex of 40-week-old ddY mice was useful for evaluation of the pathogenesis of renal involvement in the early stage of IgA nephropathy. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:15:07