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Titolo:
PROSPECTIVE SCREENING OF DYSPEPTIC PATIENTS BY HELICOBACTER-PYLORI SEROLOGY - A SAFE POLICY
Autore:
VAIRA D; STANGHELLINI V; MENEGATTI M; PALLI D; CORINALDESI R; MIGLIOLI M; BARBARA L; ALVISI V; BAJELI PF; PORRO GB; DIMARIO F; PLEBANI M; DOBRILLA G; FRANCAVILLA A; GASBARRINI G; MAZZACCA G; PALLONE F; PONZETTO A; REALDI G; VIGNERI S;
Indirizzi:
SANT ORSOLA HOSP,MED CLIN 1,VIA MASSARENTI 9 I-40138 BOLOGNA ITALY UNIV BOLOGNA,MED CLIN 1 BOLOGNA ITALY UNIV FERRARA,GI UNIT EMILIA ROMAGNA ITALY UNIV SIENA,GI UNIT TOSCANA ITALY SACCO HOSP,GI UNIT MILAN LOMBARDIA ITALY UNIV PADUA,GI UNIT VENETO FRIULI VENEZIA ITALY GI UNIT BOLZANO TRENTINO ALTO A ITALY UNIV BARI,GI UNIT PUGLIA BASILICATA ITALY UNIV ROME,MED CLIN 1 LAZIO ITALY UNIV NAPLES,GI UNIT CAMPANIA ITALY UNIV CHIETI,DEPT INTERNAL MED MARCHE MOLISE ITALY UNIV CATANZARO,GI UNIT CALABRIA ITALY SG BATTISTA HOSP,GI UNIT TURIN ITALY UNIV SASSARI,MED CLIN 1 SARDINIA ITALY UNIV PALERMO,DEPT INTERNAL MED SICILY ITALY UNIV AQUILA,CATTEDRA ENDOSCOPIA I-67100 LAQUILA ITALY UNIV AQUILA,LAB ANAL I-67100 LAQUILA ITALY UNIV AQUILA,DIV GASTROENTEROL I-67100 LAQUILA ITALY UNIV CHIETI CHIETI ITALY OSPED PESCARA,DIV GASTROENTEROL & ANAT PATOL PESCARA ITALY OSPED PENNE,DIV MED INTERNA PENNE ITALY OSPED TERMOLI,DIV GASTROENTEROL CHIETI ITALY OSPED VASTO,DIV GASTROENTEROL VASTO ITALY UNIV REGGIO CALABRIA,POLICLIN MATER DOMINI,CATTEDRA GASTROENTEROL CATANZARO ITALY OSPED CIACCIO,DIV GASTROENTEROL CATANZARO ITALY OSPED CIACCIO,LAB ANAL CATANZARO ITALY OSPED S GIOVANNI DI DIO,DIV GASTROENTEROL CROTONE ITALY OSPED E MORELLI,DIV GASTROENTEROL REGGIO CALABRIA ITALY OSPED SG MOSCATI,DIV GASTROENTEROL AVELLINO ITALY OSPED G MOSCATI AVERSA,DIV GASTROENTEROL AVELLINO ITALY OSPED CIVILE CASERTA,DIV GASTROENTEROL CASERTA ITALY OSPED S MARIA OLMO,DIV GASTROENTEROL SALERNO ITALY UNIV NAPOLIE,CATTEDRA GASTROENTEROL NAPLES ITALY OSPED VECCHIO PELLEGRINI,DIV GASTROENTEROL NAPLES ITALY OSPED MARESCA TORRE DEL GRECCO,DIV GASTROENTEROL NAPLES ITALY UNIV BOLOGNA,MED CLIN 1 BOLOGNA ITALY OSPED MIL,DIV GASTROENTEROL BOLOGNA ITALY OSPED MIL,LAB ANAL BOLOGNA ITALY OPSED RAMAZZINI DI CARPI,LAB ANAL CARPI ITALY OPSED RAMAZZINI DI CARPI,DIV GASTROENTEROL CARPI ITALY OSPED GEN PROVINCIALE M BUFALINI,DIV GASTROENTEROL CESENA ITALY OSPED GEN PROVINCIALE M BUFALINI,LAB ANAL CESENA ITALY UNIV FERRARA,CATTEDRA GASTROENTEROL I-44100 FERRARA ITALY OSPED GEN MORGAGNI FORLI ITALY OSPED IMOLA,DIV GASTROENTEROL IMOLA ITALY OSPED IMOLA,LAB ANAL IMOLA ITALY OSPED LUGO,LAB ANAL LUGO ITALY OSPED LUGO,DIV GASTROENTEROL LUGO ITALY OSPED S MARIA NUOVA,SERV ENDOSCOPIA DIGEST REGGIO EMILIA ITALY OSPED INFIRMI,DIV GASTROENTEROL RIMINI ITALY UNIV ROME,POLICLIN GEMELLI,MED CLIN 1 ROME ITALY POLITECN MIL,SERV ENDOSCOPIA DIGEST ROME ITALY OSPED RIUNITI BERGAMO,DIV GASTROENTEROL I-24100 BERGAMO ITALY OSPED CREMONA,DIV GASTROENTEROL CREMONA ITALY OSPED CREMONA,LAB ANAL CREMONA ITALY OSPED C POMA MANTOVA,DIV GASTROENTEROL,LAB ANAL & ANAT PATOL MANTUA ITALY OSPED L SACCO,DIV GASTROENTEROL MILAN ITALY UNIV MILAN MILAN ITALY OSPED TREVIGLIO,DIV GASTROENTEROL BERGAMO ITALY OSPED TREVIGLIO,LAB ANAL BERGAMO ITALY POLICLIN S MARCO,DIV GASTROENTEROL BERGAMO ITALY OSPED SPIRITO,DIV MED INTERNA INTRAZEREBRALEN CUENO ITALY OSPED CIVILE CUORGNE,LAB ANAL TURIN ITALY OSPED CIVILE CUORGNE,DIV GASTROENTEROL TURIN ITALY OSPED CIVILE,DIV GASTROENTEROL TURIN ITALY OSPED CIVILE,REPARTO CHIRURG ANAT PATOL TURIN ITALY OSPED INFIRMI,LAB ANAL TURIN ITALY OSPED INFIRMI,DIV GASTROENTEROL TURIN ITALY OSPED SAN PAOLO,DIV MED SAVONA ITALY OSPED SAN PAOLO,LAB ANAL SAVONA ITALY OSPED G BATTISTA,DIPARTIMENTO GASTROENTEROL MOLINETTE TORINO ITALY OSPED MAURIZIANO UMBERTO 1,DIV GASTROENTEROL,LAB ANAL & ANAT PATOL TURIN ITALY OSPED S ANDREA VERCELLI,DIV GEN MED VERCELLI ITALY OSPED S ANDREA VERCELLI,LAB ANAL VERCELLI ITALY OSPED MIULLI ACQUAVIVA FONTI,DIV GASTROENTEROL BARI ITALY OSPED MIULLI ACQUAVIVA FONTI,LAB ANAL BARI ITALY UNIV BARI,CATTEDRA GASTROENTEROL BARI ITALY OSPED DE BELLIS CASTELLANA GROTTE,DIV GASTROENTEROL BARI ITALY OSPED DE BELLIS CASTELLANA GROTTE,BIOCHEM LAB BARI ITALY OSPED RIUNITI FOGGIA,DIV GASTROENTEROL FOGGIA ITALY OSPED RIUNITI FOGGIA,LAB ANAL FOGGIA ITALY OSPED CIVILE OSTUNI,DIV GASTROENTEROL OSTUNI BRINDISI ITALY OSPED CIVILE OSTUNI,LAB ANAL OSTUNI BRINDISI ITALY OSPED CASA SOLLIEVO SOFFERENZA,DIV GASTROENTEROL SAN GIOVANNI ROTO FOGGIA ITALY OSPED CASA SOLLIEVO SOFFERENZA,LAB ANAL SAN GIOVANNI ROTO FOGGIA ITALY UNIV CAGLIARI,MED CLIN I-09124 CAGLIARI ITALY OSPED CIVILE CAGLIARI,DIV GASTROENTEROL CAGLIARI ITALY UNIV SASSARI,MED CLIN I-07100 SASSARI ITALY UNIV SASSARI,CLIN CHIRURG I-07100 SASSARI ITALY OSPED CIVILE SASSARI,DIV MED INTERNA 1 SASSARI ITALY OSPED CIVILE SASSARI,DIV MED INTERNA 2 SASSARI ITALY UNIV CATANIA,INST MED INTERNA I-95124 CATANIA ITALY OSPED VITTORIO EMANUELE,CATTEDRA DIAGNOST & CHIRURG ENDOSCOP CATANIA ITALY OSPED S GIACOMO,DIV MED INTERNA LICATA ARGIGENTO ITALY OSPED S GIACOMO,LAB ANAL LICATA ARGIGENTO ITALY UNIV MESSINA,CATTEDRA DIAGNOST & CHIRURG ENDOSCOPIA I-98100 MESSINA ITALY UNIV MESSINA,LAB ANAL I-98100 MESSINA ITALY OSPED BUCCHERI LA FERLA,LAB ANAL PALERMO ITALY OSPED VILLA SOFIA,SERV ENDOSCOPIA PALERMO ITALY OSPED VILLA SOFIA,LAB ANAL PALERMO ITALY
Titolo Testata:
Endoscopy
fascicolo: 7, volume: 29, anno: 1997,
pagine: 595 - 601
SICI:
0013-726X(1997)29:7<595:PSODPB>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER DISEASE; ENDOSCOPY; MANAGEMENT; SUBGROUPS; THERAPY; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
D. Vaira et al., "PROSPECTIVE SCREENING OF DYSPEPTIC PATIENTS BY HELICOBACTER-PYLORI SEROLOGY - A SAFE POLICY", Endoscopy, 29(7), 1997, pp. 595-601

Abstract

Background and Study Aims: Endoscopic screening of all dyspeptic patients is not cost-effective, nor is it feasible in many health-care delivery systems, To select the most appropriate candidates, various preendoscopic screening strategies have been proposed, some of which include Helicobacter pylori serology and patient age, We assessed the valueof these two criteria in preendoscopic screening of a large series ofdyspeptic patients, and compared the results obtained in a referral hospital (university center with an extensive H. pylori research program) with those in nonreferral hospitals (participating centers that didnot have such a program). Patients and Methods: Blood samples for determination of anti-H. pylori IgG antibody were collected from patientswith uninvestigated dyspepsia undergoing endoscopy at one referral hospital and in 93 nonreferral hospitals throughout Italy, For IgG antibody assay, an inhouse enzyme-linked immunosorbent assay (ELISA) technique was used in the referral hospital, while a commercial kit was usedin the nonreferral hospitals. Results: A total of 1638 patients were evaluated at the referral hospital (845 men and 793 women, mean age 46.1 years, range 18-89), and 3281 at the nonreferral hospitals (1718 men and 1563 women, mean age 38.8, range 18-96), respectively, If endoscopy had not been performed in patients who were seronegative for H. pylori and younger than 45 years, 19% versus 17.5 % of the tests would have been avoided in the referral and nonreferral hospitals, respectively, while six of 304 ulcers (2 %) and no cancers would have been missed versus 35 of 557 ulcers (6.3 %) and two of 557 cancers (0.3 %). Conclusions: A screening strategy based on age and H. pylori serology is avalid means of selecting dyspeptic patients for endoscopy; however, the policy needs further refinement for use in nonreferral hospitals.

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Documento generato il 15/07/20 alle ore 21:35:29