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Titolo:
EPSTEIN-BARR VIRUS-INDUCED GENE-3 AND THE P35 SUBUNIT OF INTERLEUKIN-12 FORM A NOVEL HETERODIMERIC HEMATOPOIETIN
Autore:
DEVERGNE O; BIRKENBACH M; KIEFF E;
Indirizzi:
CHANNING LABS,181 LONGWOOD AVE BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT MED BOSTON MA 02115 HARVARD UNIV,SCH MED,DEPT MICROBIOL & MOL GENET BOSTON MA 02115 BRIGHAM & WOMENS HOSP,DEPT MED BOSTON MA 02115 UNIV CHICAGO,DEPT PATHOL CHICAGO IL 60637 UNIV CHICAGO,CTR CANC RES CHICAGO IL 60637
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 94, anno: 1997,
pagine: 12041 - 12046
SICI:
0027-8424(1997)94:22<12041:EVGATP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOKINE RECEPTOR SUPERFAMILY; BIOLOGIC ACTIVITY; IL-12 RECEPTOR; CLONING; CELLS; EXPRESSION; COMPLEX; MEMBER; BETA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
O. Devergne et al., "EPSTEIN-BARR VIRUS-INDUCED GENE-3 AND THE P35 SUBUNIT OF INTERLEUKIN-12 FORM A NOVEL HETERODIMERIC HEMATOPOIETIN", Proceedings of the National Academy of Sciences of the United Statesof America, 94(22), 1997, pp. 12041-12046

Abstract

The Epstein-Barr virus-induced gene 3 (EBI3) is a novel soluble hematopoietin component related to the p40 subunit of interleukin 12 (IL-12), When EBI3 was expressed in cells, it accumulated in the endoplasmicreticulum and associated with the molecular chaperone calnexin, indicating that subsequent processing and secretion might be dependent on association with a second subunit, Coimmunoprecipitations from lysates and culture media of cells transfected with expression vectors for EBI3 and/or the p35 subunit of IL-12 now reveal a specific association ofEBI3 with p35, Coexpression of EBB and p35 mutually facilitates theirsecretion, Most importantly, a large fraction of p35 in extracts of the trophoblast component of a human full-term normal placenta specifically coimmunoprecipitated with EBIS, indicating that EBI3 is in a heterodimer with p35, in vivo. Because EBI3 is expressed in EBV-transformed B lymphocytes, tonsil, spleen, and placental trophoblasts, the EBI3/p35 heterodimer is likely to be an important immunomodulator.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:37:38