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Titolo:
PROTEINASE-INHIBITOR-I AND PROTEINASE-INHIBITOR-II FROM POTATOES SPECIFICALLY BLOCK UV-INDUCED ACTIVATOR PROTEIN-1 ACTIVATION THROUGH A PATHWAY THAT IS INDEPENDENT OF EXTRACELLULAR SIGNAL-REGULATED KINASES, C-JUN N-TERMINAL KINASES, AND P38 KINASE
Autore:
HUANG CS; MA WY; RYAN CA; DONG ZG;
Indirizzi:
UNIV MINNESOTA,HORMEL INST,801 16TH AVE NE AUSTIN MN 55912 UNIV MINNESOTA,HORMEL INST AUSTIN MN 55912 WASHINGTON STATE UNIV,INST BIOL CHEM PULLMAN WA 99164
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 22, volume: 94, anno: 1997,
pagine: 11957 - 11962
SICI:
0027-8424(1997)94:22<11957:PAPFPS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-INDUCED TRANSFORMATION; AP-1 ACTIVITY; C3H-10T1/2 CELLS; STRESS; YEAST; FOS; PROLIFERATION; PHOSPHATASE; COMPONENTS; TYROSINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
C.S. Huang et al., "PROTEINASE-INHIBITOR-I AND PROTEINASE-INHIBITOR-II FROM POTATOES SPECIFICALLY BLOCK UV-INDUCED ACTIVATOR PROTEIN-1 ACTIVATION THROUGH A PATHWAY THAT IS INDEPENDENT OF EXTRACELLULAR SIGNAL-REGULATED KINASES, C-JUN N-TERMINAL KINASES, AND P38 KINASE", Proceedings of the National Academy of Sciences of the United Statesof America, 94(22), 1997, pp. 11957-11962

Abstract

Solar UV irradiation is the causal factor for the increasing incidence of human skin carcinomas, The activation of the transcription factoractivator protein-1 (AP-1) has been shown to be responsible for the tumor promoter action of UV light in mammalian cells, We demonstrate that proteinase inhibitor I (Inh I) and II (Inh II) from potato tubers, when applied to mouse epidermal JB6 cells, block UV-induced AP-1 activation, The inhibition appears to be specific for UV-induced signal transduction for AP-1 activation, because these inhibitors did not block UV-induced p53 activation nor did they exhibit any significant influence on epidermal growth factor-induced AP-1 transactivation. Furthermore, the inhibition of UV-induced AP-1 activity occurs through a pathwaythat is independent of extracellular signal-regulated kinases and c-Jun N-terminal kinases as well as P38 kinases, Considering the important role of AP-1 in tumor promotion, it is possible that blocking UV-induced AP-1 activity by Inh I or Inh II may be functionally linked to irradiation-induced cell transformation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:18:42