Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
THEORETICAL AND EMPIRICAL ISSUES FOR MARKER-ASSISTED BREEDING OF CONGENIC MOUSE STRAINS
Autore:
MARKEL P; SHU P; EBELING C; CARLSON GA; NAGLE DL; SMUTKO JS; MOORE KJ;
Indirizzi:
MILLENNIUM PHARMACEUT,640 MEM DR CAMBRIDGE MA 02139 MILLENNIUM PHARMACEUT CAMBRIDGE MA 02139 MCLAUGHLIN RES INST GREAT FALLS MT 59405
Titolo Testata:
Nature genetics
fascicolo: 3, volume: 17, anno: 1997,
pagine: 280 - 284
SICI:
1061-4036(1997)17:3<280:TAEIFM>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-E; DEFICIENT MICE; HYPERCHOLESTEROLEMIA; ATHEROSCLEROSIS; SUSCEPTIBILITY; INTERVALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
P. Markel et al., "THEORETICAL AND EMPIRICAL ISSUES FOR MARKER-ASSISTED BREEDING OF CONGENIC MOUSE STRAINS", Nature genetics, 17(3), 1997, pp. 280-284

Abstract

Congenic breeding strategies are becoming increasingly important as agreater number of complex trait linkages are identified. Traditionally, the development od a congenic strain Ras been a time-consuming endeavour, requiring ten generations of backcrosses. The recent advent of a dense molecular genetic map of the mouse permits methods that can reduce the time needed for congenic-strain production by 18-24 months. We present a theoretical evaluation of marker-assisted congenic production and provide the empirical data that support it. We present this 'speed congenic' method in a user-friendly manner to encourage other investigators to pursue this or similar methods of congenic production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 15:10:44