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Titolo:
SIMULTANEOUS MONITORING OF INHIBITION OF SEROTONIN UPTAKE BY PLATELETS AND PLASMA DRUG CONCENTRATIONS FOLLOWING ADMINISTRATION OF DULOXETINE, A NEW ANTIDEPRESSANT CANDIDATE, TO HEALTHY-VOLUNTEERS
Autore:
ISHIGOOKA J; NAGATA E; TAKAHASHI A; SUGIYAMA T; UCHIUMI M; TSUKAHARA T; MURASAKI M; MIURA S; OGUMA T; YANO Y;
Indirizzi:
KITASATO UNIV,SCH MED,DEPT PSYCHIAT,2-1-1 ASAMIZODAI SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DIV BIOCHEM SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH ALLIED SCI SAGAMIHARA KANAGAWA 228 JAPAN SHIONOGI & CO LTD,SHIONOGI RES LABS OSAKA 553 JAPAN
Titolo Testata:
Current therapeutic research
fascicolo: 10, volume: 58, anno: 1997,
pagine: 679 - 692
SICI:
0011-393X(1997)58:10<679:SMOIOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 IMIPRAMINE; BINDING; 5-HYDROXYTRYPTAMINE; RAT; CITALOPRAM; NEURONS; BRAIN; BLOOD;
Keywords:
5-HYDROXYTRYPTAMINE (SEROTONIN); PLATELET; DULOXETINE; UPTAKE INHIBITION; EX VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
J. Ishigooka et al., "SIMULTANEOUS MONITORING OF INHIBITION OF SEROTONIN UPTAKE BY PLATELETS AND PLASMA DRUG CONCENTRATIONS FOLLOWING ADMINISTRATION OF DULOXETINE, A NEW ANTIDEPRESSANT CANDIDATE, TO HEALTHY-VOLUNTEERS", Current therapeutic research, 58(10), 1997, pp. 679-692

Abstract

Duloxetine is a new antidepressant candidate drug with inhibitory effects on norepinephrine and serotonin (5-HT) uptake. In the present study, simultaneous monitoring of the inhibition of 5-HT uptake by platelets and plasma drug concentrations was carried out in healthy volunteers during and after administration of 20 mg of duloxetine once daily for 1 week. Inhibition by duloxetine of 5-HT uptake by platelets and the appearance of the drug in plasma occurred simultaneously, and a strong inhibition greater than 80% to 90% was maintained during the experimental period. Until 2 days after the final administration, the observed values for 5-HT uptake inhibition rate were in good agreement with those simulated from total, but not final, plasma concentrations of duloxetine (r = .9846). Moreover, on the fourth day after the final administration, the observed values mere even higher than the simulated ones (observed mean value, 40.5 +/- 14.6; simulated value, 13.3). These results show that uptake of 5-HT is inhibited strongly and for a long period in the subjects taking duloxetine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 15:59:09