Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IONTOPHORESIS OF POLY-L-LYSINES - THE ROLE OF MOLECULAR-WEIGHT
Autore:
TURNER NG; FERRY L; PRICE M; CULLANDER C; GUY RH;
Indirizzi:
PARC AFFAIRES INT,CTR INTERUNIV RECH ENSEIGNEMENT,CAMPUS UNIV F-74166ARCHAMPS FRANCE UNIV CALIF SAN FRANCISCO,DEPT BIOPHARMACEUT SCI SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM SAN FRANCISCO CA 94143 NOVARTIS,DRUG DELIVERY SYST E HANOVER NJ 07936
Titolo Testata:
Pharmaceutical research
fascicolo: 10, volume: 14, anno: 1997,
pagine: 1322 - 1331
SICI:
0724-8741(1997)14:10<1322:IOP-TR>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCISED HUMAN-SKIN; TRANSDERMAL IONTOPHORESIS; MOUSE SKIN; TRANSPORT; DELIVERY; FLOW; ENHANCEMENT; HORMONE; INVITRO;
Keywords:
IONTOPHORESIS; MOLECULAR WEIGHT; SKIN; CONFOCAL MICROSCOPY; DRUG DELIVERY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
N.G. Turner et al., "IONTOPHORESIS OF POLY-L-LYSINES - THE ROLE OF MOLECULAR-WEIGHT", Pharmaceutical research, 14(10), 1997, pp. 1322-1331

Abstract

Purpose. (1) To determine the extent of iontophoretic transport as a function of molecular weight (MW) of the penetrant; and (2) to visually and quantitatively characterize the iontophoretic transport pathways(follicular if) versus nonfollicular (NF)) of the fluorescently-labeled poly-L-lysines employed. Methods. A series of fluorescently-labeledpoly-L-lysines (FITC-PLLs) [4 KDa, 7 KDa and 26 KDa] were used to study the extent and distribution of iontophoretic skin penetration as a function of MW using laser scanning confocal microscopy (LSCM). Results. It was found that, relative to the passive controls, and under the electrical conditions considered, iontophoresis greatly enhanced the penetration of the 4 KDa analog, slightly elevated the delivery of the 7 KDa FITC-PLL, but had no effect on the transport of the larger 26 KDa FITC-PLL. Quantitative analyses of LSCM images revealed that iontophoresis increased transport via F pathways only slightly more than thatthrough NF pathways for the 4 KDa and 7 KDa FITC-PLL molecules. Conclusions. It is visually apparent that the iontophoretic transport pathways taken are importantly determined by the physicochemical properties(including size and charge) of the penetrant. The results presented here demonstrate an inverse dependence of iontophoretic delivery upon the MW of the penetrant.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:56:29