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Titolo:
INVOLVEMENT OF AFSA IN A-FACTOR BIOSYNTHESIS AS A KEY ENZYME
Autore:
ANDO N; MATSUMORI N; SAKUDA S; BEPPU T; HORINOUCHI S;
Indirizzi:
UNIV TOKYO,GRAD SCH AGR & LIFE SCI,DEPT BIOTECHNOL,BUNKYO KU TOKYO 113 JAPAN UNIV TOKYO,GRAD SCH AGR & LIFE SCI,DEPT BIOTECHNOL,BUNKYO KU TOKYO 113 JAPAN UNIV TOKYO,GRAD SCH AGR & LIFE SCI,DEPT APPL BIOL CHEM,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Journal of antibiotics
fascicolo: 10, volume: 50, anno: 1997,
pagine: 847 - 852
SICI:
0021-8820(1997)50:10<847:IOAIAB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
VIRGINIAE BUTANOLIDE-A; STREPTOMYCES-GRISEUS; BUTYROLACTONE AUTOREGULATOR; ANTHRACYCLINE BIOSYNTHESIS; SECONDARY METABOLISM; CLONING; DETERMINANT; AUTOINDUCER; PROTEIN; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
N. Ando et al., "INVOLVEMENT OF AFSA IN A-FACTOR BIOSYNTHESIS AS A KEY ENZYME", Journal of antibiotics, 50(10), 1997, pp. 847-852

Abstract

The afsA gene of Streptomyces griseus has been postulated to encode akey enzyme for A-factor biosynthesis from primary metabolites commonly present in Streptomyces strains. Escherichia call cells harboring afsA under the control of the T7 promoter specified distinct A-factor activity in the culture broth, as determined by induction of streptomycin production and aerial mycelium and spore formation in an A-factor-deficient S. griseus mutant strain. Production of the substance(s) having A-factor activity was inhibited by cerulenin, an inhibitor of fatty acid biosynthesis. These observations suggest that afsA encodes a key enzyme in the A-factor biosynthetic pathway in which a P-keto acid derived from fatty acid biosynthesis and a glycerol derivative serve as precursors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 02:03:33