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Titolo:
EFFECT OF POLICOSANOL ON CIRCULATING ENDOTHELIAL-CELLS IN EXPERIMENTAL-MODELS IN SPRAGUE-DAWLEY RATS AND IN RABBITS
Autore:
NOA M; MAS R; MESA R;
Indirizzi:
NATL CTR SCI RES,CTR NAT PROD,HISTOL LAB,25 AVE & 158 ST,POB 6990 HAVANA 6880 CUBA
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 10, volume: 49, anno: 1997,
pagine: 999 - 1002
SICI:
0022-3573(1997)49:10<999:EOPOCE>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUCCESSIVE DOSE INCREASES; II HYPERCHOLESTEROLEMIA; CAROTID-ARTERY; ATHEROSCLEROTIC LESIONS; ANGINA-PECTORIS; LIPID PROFILE; TOLERABILITY; FLUNARIZINE; PREVENTION; EFFICACY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M. Noa et al., "EFFECT OF POLICOSANOL ON CIRCULATING ENDOTHELIAL-CELLS IN EXPERIMENTAL-MODELS IN SPRAGUE-DAWLEY RATS AND IN RABBITS", Journal of Pharmacy and Pharmacology, 49(10), 1997, pp. 999-1002

Abstract

The effect of policosanol on circulating endothelial cells has been studied in different experimental models with endothelium damage. Oral administration of 25mgkg(-1) policosanol to Sprague-Dawley rats resulted in significant protection of the endothelial lining against the desquamating effect of citrate. Oral administration of 5mgkg(-1) policosanol to spontaneously hypertensive rats (SHR) resulted in a significantreduction of circulating endothelial cells compared with controls. Moreover, comparison between groups revealed a lower frequency of aorticlesions in policosanol-treated animals than in controls. On the otherhand, administration of 5mgkg(-1) policosanol to rabbits with intimalhyperplasia induced by cuff placement in the carotid artery resulted in levels of circulating endothelial cells significantly lower than incontrols. These results demonstrate the protective effect of policosanol in different experimental models and suggest its potential for endothelial protection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 11:11:52