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Titolo:
REGIONAL CEREBRAL BLOOD-FLOW DURING THE WISCONSIN CARD SORT TEST IN SCHIZOTYPAL PERSONALITY-DISORDER
Autore:
BUCHSBAUM MS; TRESTMAN RL; HAZLETT E; SIEGEL BV; SCHAEFER CH; LUUHSIA C; TANG C; HERRERA S; SOLIMANDO AC; LOSONCZY M; SERBY M; SILVERMAN J; SIEVER LJ;
Indirizzi:
CUNY MT SINAI SCH MED,DEPT PSYCHIAT,BOX 1505,1 GUSTAVE L LEVY PL NEW YORK NY 10029 UNIV CALIF LOS ANGELES,DEPT PSYCHIAT LOS ANGELES CA 90073 W LOS ANGELES DEPT VET AFFAIRS MED CTR LOS ANGELES CA 90073 BRONX VET AFFAIRS MED CTR,DEPT PSYCHIAT BRONX NY 10468 BRONX VET AFFAIRS MED CTR,DEPT NUCL MED BRONX NY 10468 FDR VET AFFAIRS MED CTR,PSYCHIAT SERV MONTROSE NY 10548
Titolo Testata:
Schizophrenia research
fascicolo: 1, volume: 27, anno: 1997,
pagine: 21 - 28
SICI:
0920-9964(1997)27:1<21:RCBDTW>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSOLATERAL PREFRONTAL CORTEX; HIPPOCAMPAL PYRAMIDAL CELL; FRONTAL-LOBE LESIONS; SCHIZOPHRENIC-PATIENTS; PHYSIOLOGICAL DYSFUNCTION; TEST-PERFORMANCE; ACTIVATION; SPECT; ABNORMALITIES; AMPHETAMINE;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; FRONTAL LOBE; NEUROPSYCHOLOGY; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Buchsbaum et al., "REGIONAL CEREBRAL BLOOD-FLOW DURING THE WISCONSIN CARD SORT TEST IN SCHIZOTYPAL PERSONALITY-DISORDER", Schizophrenia research, 27(1), 1997, pp. 21-28

Abstract

Regional cerebral blood flow (rCBF) was measured by single photon emission computed tomography in 10 patients with schizotypal personality disorder (SPD) and nine age-and sex-matched normal volunteers. Subjects performed both the Wisconsin Card Sort Test (WCST) and a control task, the Symbol Matching Test (SMT). Four-way analyses of variance were performed to assess relative rCBF of the prefrontal cortex and of the medial temporal region. Normal volunteers showed more marked activation in the precentral gyrus, while SPD patients showed greater activation in the middle frontal gyrus. Relative flow in the left prefrontal cortex was correlated with better WCST performance in normal volunteers. SPD patients, however, showed no such correlations in the left prefrontal cortex, but demonstrated correlations of good and bad performancewith CBF in the right middle and inferior frontal gyrus, respectively. Thus, at least some SPD patients demonstrate abnormal patterns of prefrontal activation, perhaps as a compensation for dysfunction in other regions. (C) 1997 Elsevier Science B.V.

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Documento generato il 18/01/20 alle ore 10:33:21