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Titolo:
STATUS EPILEPTICUS-INDUCED ALTERATIONS IN METABOTROPIC GLUTAMATE-RECEPTOR EXPRESSION IN YOUNG AND ADULT RATS
Autore:
ARONICA EM; GORTER JA; PAUPARD MC; GROOMS SY; BENNETT MVL; ZUKIN RS;
Indirizzi:
YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,1300 MORRIS PK AVE BRONX NY 10461 YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI BRONX NY 10461
Titolo Testata:
The Journal of neuroscience
fascicolo: 21, volume: 17, anno: 1997,
pagine: 8588 - 8595
SICI:
0270-6474(1997)17:21<8588:SEAIMG>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; CENTRAL-NERVOUS-SYSTEM; BRAIN DAMAGE SYNDROME; AMINO-ACID RECEPTORS; MESSENGER-RNA; KAINIC ACID; SYNAPTIC TRANSMISSION; INSITU HYBRIDIZATION; CEREBELLAR CORTEX; LIMBIC SEIZURES;
Keywords:
METABOTROPIC GLUTAMATE RECEPTORS; RECEPTOR MESSENGER-RNAS; DEVELOPMENT; HIPPOCAMPUS; STATUS EPILEPTICUS; SEIZURES; EPILEPSY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Aronica et al., "STATUS EPILEPTICUS-INDUCED ALTERATIONS IN METABOTROPIC GLUTAMATE-RECEPTOR EXPRESSION IN YOUNG AND ADULT RATS", The Journal of neuroscience, 17(21), 1997, pp. 8588-8595

Abstract

In adult rats, kainic acid induces status epilepticus and delayed, selective cell loss of pyramidal neurons in the hippocampal CA3. In pup rats, kainate induces status epilepticus but not the accompanying neuronal cell death. The precise mechanisms underlying this age-dependent vulnerability to seizure-induced cell death are not understood. Metabotropic glutamate receptors (mGluRs) are developmentally and spatially regulated throughout the hippocampus and are implicated in seizure-induced damage. In the present study we used in situ hybridization to examine possible changes in mGluR expression at the level of the hippocampus after status epilepticus in postnatal day 10 (P10) pup and adult (P40) rats. Status epilepticus did not alter expression of mGluR1, mGluR3, or mGluR5 mRNAs. In pup and adult rats, status epilepticus induceda reduction in expression of mGluR2 mRNA in granule cells of the dentate gyrus. This change could lead to augmented glutamate release at messy fiber synapses on CA3 pyramidal cells and thereby promote hyperexcitation. In pup but not adult rats, mGluR4 mRNA expression was enhanced in CA3 pyramidal neurons. Upregulation of presynaptic mGluR4 in pup CA3 neurons could lead to reduced transmitter release from CA3 axons, including recurrent collaterals, thereby reducing vulnerability of neonatal CA3 neurons to seizure-induced damage. These findings indicate that status epilepticus affects mGluR expression in a gene-and cell-specific manner, and that these changes vary with the developmental stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 08:14:11