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Titolo:
RHINAL CORTEX REMOVAL PRODUCES AMNESIA FOR PREOPERATIVELY LEARNED DISCRIMINATION PROBLEMS BUT FAILS TO DISRUPT POSTOPERATIVE ACQUISITION AND RETENTION IN RHESUS-MONKEYS
Autore:
THORNTON JA; ROTHBLAT LA; MURRAY EA;
Indirizzi:
NIMH,NEUROPSYCHOL LAB,BLDG 49,ROOM 1B80,49 CONVENT DR BETHESDA MD 20892 NIMH,NEUROPSYCHOL LAB BETHESDA MD 20892 GEORGE WASHINGTON UNIV,DEPT PSYCHOL WASHINGTON DC 20052
Titolo Testata:
The Journal of neuroscience
fascicolo: 21, volume: 17, anno: 1997,
pagine: 8536 - 8549
SICI:
0270-6474(1997)17:21<8536:RCRPAF>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETROGRADE-AMNESIA; ENTORHINAL CORTEX; INTERTRIAL INTERVALS; ANTEROGRADE AMNESIA; FORNIX TRANSECTION; SPATIAL DISCRIMINATION; TEMPORAL GRADIENT; MEMORY IMPAIRMENT; PERIRHINAL CORTEX; PARIETAL CORTEX;
Keywords:
VISUAL DISCRIMINATION; STIMULUS MEMORY; RETROGRADE AMNESIA; ENTORHINAL CORTEX; PERIRHINAL CORTEX; RHESUS MONKEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Thornton et al., "RHINAL CORTEX REMOVAL PRODUCES AMNESIA FOR PREOPERATIVELY LEARNED DISCRIMINATION PROBLEMS BUT FAILS TO DISRUPT POSTOPERATIVE ACQUISITION AND RETENTION IN RHESUS-MONKEYS", The Journal of neuroscience, 17(21), 1997, pp. 8536-8549

Abstract

To test whether the rhinal cortex (i.e., entorhinal and perirhinal cortex) plays a time-limited role in information storage, eight rhesus monkeys were trained to criterion on two sets of 60 object discrimination problems, one set at each of two different time periods separated by 15 weeks. After the monkeys had learned both sets, two groups balanced for preoperative acquisition rates were formed. One group received bilateral ablation of the rhinal cortex (n = 4), and the other was retained as an unoperated control group (n = 4). After a 2 week rest period, monkeys were assessed for retention of the object discrimination problems. Retention was significantly poorer in monkeys with removals of the rhinal cortex relative to the controls (68 vs 91 %). Although both groups showed slightly better retention of problems from the more recently learned set, there was no evidence of a differential effect ofthe cortical removal across sets (i.e., no temporal gradient). In addition, the monkeys with rhinal cortex lesions subsequently learned three new sets of 10 object discrimination problems as quickly as the controls did, thus ruling out the possibility of a gross impairment in visual perception or discrimination abilities. Furthermore, they retained these postoperatively learned object discriminations as well as the controls did. The findings indicate that the rhinal cortex is criticalfor the storage and/or retrieval of object discrimination problems that were learned up to 16 weeks before rhinal cortex ablation; however,in the absence of the rhinal cortex, efficient learning and retentionof new discrimination problems can still occur.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 10:42:39