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Titolo:
ENDOTHELIN IN CEREBROSPINAL-FLUID AND PLASMA OF PATIENTS IN THE EARLY-STAGE OF ISCHEMIC STROKE
Autore:
LAMPL Y; FLEMINGER G; GILAD R; GALRON R; SAROVAPINHAS I; SOKOLOVSKY M;
Indirizzi:
TEL AVIV UNIV,FAC MED,EDITH WOLFSON MED CTR,DEPT NEUROL IL-58100 HOLON ISRAEL TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT NEUROBIOCHEM IL-69978 TEL AVIV ISRAEL
Titolo Testata:
Stroke
fascicolo: 10, volume: 28, anno: 1997,
pagine: 1951 - 1955
SICI:
0039-2499(1997)28:10<1951:EICAPO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL VASOSPASM; RECEPTOR ANTAGONIST; CONSCIOUS RATS; BRAIN; STIMULATION; ACTIVATION; HEMORRHAGE; SUBTYPES; ARTERIES; PEPTIDE;
Keywords:
ENDOTHELINS; STROKE, ACUTE; CEREBROSPINAL FLUID; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
Y. Lampl et al., "ENDOTHELIN IN CEREBROSPINAL-FLUID AND PLASMA OF PATIENTS IN THE EARLY-STAGE OF ISCHEMIC STROKE", Stroke, 28(10), 1997, pp. 1951-1955

Abstract

Background and Purpose Endothelin 1 (ET-1), a highly potent endogenous vasoactive peptide, exerts a sustained vasoconstrictive effect on cerebral vessels. Elevation of ET-1 in plasma has been reported 1 to 3 days after ischemic stroke. Since we assumed that a much faster and more intense response may be observed in the cerebrospinal fluid (CSF) and since an increase in concentration of ET-1 in the CSF may cause constriction of cerebral vessels and eventually influence the neurologicaloutcome, we measured ET-1 values in the CSF within 18 hours of strokeonset and compared the values with those in the plasma. Methods Twenty-six consecutive patients with acute stroke were clinically evaluatedaccording to the modified Matthew Scale and underwent two repeat CT scans. Within 5 to 18 hours of stroke onset, lumbar puncture and blood samples were concomitantly obtained and tested; ET-1 levels in CSF andplasma of these patients were analyzed by radioimmunoassay and compared with the levels of a control group of patients with no neurologicaldisease. Results The mean CSF concentration of ET-1 in the CSF of stroke patients was 16.06+/-4.9 pg/mL, compared with 5.51+/-1.47 pg/mL inthe control group (P<.001). It was significantly higher in cortical infarcts (mean, 17.7+/-4.1 pg/mL) than in subcortical lesions (mean, 10.77+/-4.1 pg/mL) (P<.001) and significantly correlated with the volumeof the lesion (P=.003). The correlation between ET-1 levels in the CSF and the Matthew Scale score was less significant (P=.05). Plasma ET-1 level was not elevated in any group. Conclusions ET-1 is found to besignificantly elevated in the CSF of stroke patients during the 18 hours after stroke. No elevation was demonstrated in plasma at this timeperiod. ET-1 may be used as an additional indicator of ischemic vascular events in the early diagnosis of stroke. The dissimilarity betweenthe CSF and plasma ET-1 concentrations may lead also to an hypothesisthat there is a vasoconstrictive effect on the cerebral vessels or a neuronal effect caused by ET-1 in the mechanism of the progression of brain ischemia.

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Documento generato il 02/12/20 alle ore 16:51:44