Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
GENERAL AND CARDIAC TOXICITY OF DOXORUBICIN-LOADED GELATIN NANOPARTICLES
Autore:
LEO E; ARLETTI R; FORNI F; CAMERONI R;
Indirizzi:
UNIV MODENA,DIPARTIMENTO SCI FARMACEUT,VIA CAMPI 183 I-41100 MODENA ITALY UNIV MODENA,DIPARTIMENTO SCI FARMACEUT I-41100 MODENA ITALY
Titolo Testata:
Il Farmaco
fascicolo: 6-7, volume: 52, anno: 1997,
pagine: 385 - 388
SICI:
0014-827X(1997)52:6-7<385:GACTOD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYALKYLCYANOACRYLATE NANOPARTICLES; DRUG-CARRIER; RAT HEPATOMA; MICROSPHERES; ADRIAMYCIN; CARDIOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
E. Leo et al., "GENERAL AND CARDIAC TOXICITY OF DOXORUBICIN-LOADED GELATIN NANOPARTICLES", Il Farmaco, 52(6-7), 1997, pp. 385-388

Abstract

General and cardiac toxicity of doxorubicin loaded gelatin nanoparticles cross-linked by glutaraldheyde were investigated in healthy rats. The rats were treated with free doxorubicin (DXR), unloaded nanoparticles (UNp), physical mixture of doxorubicin, and unloaded nanoparticles(DRX/UNp), and DXR-loaded nanoparticles (DXR-Np). Each group of animals received the same dose of DXR (3 mg/kg) via i.p. once a week. Both electrocardiogram (EGG) parameters and body weight were measured 24h before each administration. Rats treated with UNp behaved as controls. DXR/UNp provoked the same toxic effects as free DXR. On the contrary, DXR-Np resulted more toxic since significant variations of both the body weight and the ECG parameters were observed during the first week of treatment. In addition, the rats treated with DXR-Np died between the 3(rd) and the 5(th) day after the 2(nd) administration. These results demonstrate that, in these experimental conditions, the couplage of DXR to nanoparticles enhanced the cardiotoxicity of the drug. Since DXR was linked to the protein matrix of nanoparticles via glutaraldehyde, the high toxicity of DXR-loaded nanoparticles could be due to the covalent binding of the drug to the carrier.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:32:27