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Titolo:
PUTATIVE ROLES OF RETINOBLASTOMA PROTEIN IN APOPTOSIS
Autore:
DOU QP;
Indirizzi:
UNIV PITTSBURGH,SCH MED,DEPT PHARMACOL,W952,BIOMED SCI TOWER,200 LOTHROP ST PITTSBURGH PA 15213 UNIV PITTSBURGH,INST CANC PITTSBURGH PA 15213
Titolo Testata:
Apoptosis
fascicolo: 1, volume: 2, anno: 1997,
pagine: 5 - 18
SICI:
1360-8185(1997)2:1<5:PRORPI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-CYCLE CONTROL; S-PHASE ENTRY; INTERLEUKIN 1-BETA-CONVERTING ENZYME; SUSCEPTIBILITY GENE-PRODUCT; TUMOR-SUPPRESSOR PROTEIN; ADENOVIRUS E1A PROTEINS; POLY(ADP-RIBOSE) POLYMERASE; DEPENDENT KINASES; P53-MEDIATED APOPTOSIS; ERYTHROLEUKEMIA-CELLS;
Keywords:
APOPTOSIS; CDK KINASES; CELL CYCLE; ICE-LIKE PROTEASES; PHOSPHATASES; RB;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
98
Recensione:
Indirizzi per estratti:
Citazione:
Q.P. Dou, "PUTATIVE ROLES OF RETINOBLASTOMA PROTEIN IN APOPTOSIS", Apoptosis, 2(1), 1997, pp. 5-18

Abstract

Cell numbers are regulated by a balance between processes of proliferation and apoptosis (programmed cell death). Proper regulation in a cell requires an accurate co-ordination between these two processes. Indeed, it has recently been found that dysregulation of cell cycle progression is essential for the initiation of apoptosis. Retinoblastoma protein (RE) is an important tumour suppressor and a cell cycle regulator. Most recent studies suggest that RE also plays a regulatory role inthe process of apoptosis. During the onset of apoptosis, the hyperphosphorylated form of RE (p120/hyper) is converted to a hypophosphorylated form (p115/hypo), which is mediated by a specific protein-serine/ threonine phosphatase activity. The pll5/hypolRB may play an active role in the regulation of apoptosis. Accompanied by the endonucleosomal fragmentation of DNA, the newly formed p115/hypo/RB is immediately cleaved by a protease that has properties of the interleukin-1 beta-converting enzyme family. By contrast, the unphosphorylated form of RB (p110/unphos) remains uncleaved during apoptosis. Further studies suggest that p110/unphos/RB functions as an inhibitor of apoptosis. Therefore, a balance between RE phosphatases and kinases and consequent RE phosphorylation status may be important for the determination of cellular fate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:14:31