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Titolo:
PROTEIN SYNTHESIS-DEPENDENT AND FUCOSYLATION-DEPENDENT MECHANISMS IN CORTICOSTERONE FACILITATION OF LONG-TERM-MEMORY IN THE CHICK
Autore:
SANDI C; ROSE SPR;
Indirizzi:
UNIV NACL EDUC DISTANCIA,DEPT PSYCHOBIOL,CIUDAD UNIV S-N E-28040 MADRID SPAIN OPEN UNIV,BRAIN & BEHAV RES GRP MILTON KEYNES MK7 6AA BUCKS ENGLAND CSIC,INST CAJAL,PSYCHOBIOL RES GRP E-28002 MADRID SPAIN
Titolo Testata:
Behavioral neuroscience
fascicolo: 5, volume: 111, anno: 1997,
pagine: 1098 - 1104
SICI:
0735-7044(1997)111:5<1098:PSAFMI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; DAY-OLD CHICKS; GLYCOPROTEIN-SYNTHESIS; RAT HIPPOCAMPUS; AVOIDANCE TASK; BRAIN; GENE; 2-DEOXYGALACTOSE; CONSOLIDATION; AMNESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
C. Sandi e S.P.R. Rose, "PROTEIN SYNTHESIS-DEPENDENT AND FUCOSYLATION-DEPENDENT MECHANISMS IN CORTICOSTERONE FACILITATION OF LONG-TERM-MEMORY IN THE CHICK", Behavioral neuroscience, 111(5), 1997, pp. 1098-1104

Abstract

Long-term memory formation for a passive avoidance task in day-old chicks, which requires a late phase of glycoprotein fucosylation (5-8 hrposttraining), is dependent on a corticosterone action in the brain. In addition, corticosterone enhances late-phase fucosylation. In this study, the authors explored (a) to what extent the memory-facilitatingaction of corticosterone is dependent on protein fucosylation and (b)whether a protein synthesis mechanism might be involved in the steroid effects on memory and late-phase fucosylation. A combination of psychopharmacological and biochemical experiments, including the fucosylation inhibitor 2-deoxygalactose (2-DG), the protein synthesis inhibitoranisomycin (ANI), and radiolabeled fucose, indicated that the late phase of glycoprotein synthesis involved in the memory-facilitating effect of corticosterone occurs on newly synthesized proteins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:56:00