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Titolo:
THE GH-RELEASING EFFECT OF HEXARELIN, A SYNTHETIC HEXAPEPTIDE, IN NEWBORNS IS LOWER THAN IN YOUNG-ADULTS
Autore:
BARTOLOTTA E; BELLONE J; AIMARETTI G; ARVAT E; BENSO L; DEGHENGHI R; CAMANNI F; GHIGO E;
Indirizzi:
OSPED MOLINETTE,DIV ENDOCRINOL,C SO DOGLIOTTI 14 I-10126 TURIN ITALY UNIV TURIN,DEPT INTERNAL MED,DIV ENDOCRINOL TURIN ITALY UNIV TURIN,DIV AUXOL TURIN ITALY EUROPEPTIDES ARGENTEUIL FRANCE
Titolo Testata:
Journal of pediatric endocrinology & metabolism
fascicolo: 5, volume: 10, anno: 1997,
pagine: 491 - 497
SICI:
0334-018X(1997)10:5<491:TGEOHA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-I; HORMONE (GH)-RELEASING PEPTIDE; PITUITARY-CELLS; BODY-MASS; SECRETION; AGE; RAT; INSULIN; FETAL; SOMATOSTATIN;
Keywords:
GH; NEWBORNS; HEXARELIN; GHRH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
E. Bartolotta et al., "THE GH-RELEASING EFFECT OF HEXARELIN, A SYNTHETIC HEXAPEPTIDE, IN NEWBORNS IS LOWER THAN IN YOUNG-ADULTS", Journal of pediatric endocrinology & metabolism, 10(5), 1997, pp. 491-497

Abstract

The aim of the present study was to verify the CH-releasing effect ofHexarelin, a synthetic hexapeptide, in newborns who are known to haveGH hypersecretion likely due to hyperactivity of GHRH-secreting neurons while somatostatinergic activity seems not fully operative, We studied in 6 newborns (NB, 2.5 +/- 2.1 days), 12 prepubertal children (PC,9.8 +/- 0.45 yr) and 12 young adults (YA, 28.2 +/- 0.2yr) the GH response to Hexarelin (HEX, 2 mu g/kg i.v.) compared to that observed after GHRH (1 mu g/kg i.v.) in 6 NB (4.2 +/- 0.4 days), 12 PC (9.9 +/- 0.6yr) and 12 YA (31.0 +/- 1.3 yr), GH levels were assayed basally and 30 and 60 min after drug administration, In NE, mean (+/- SEM) basal GHlevels were higher while IGF-I levels were lower than those recorded in PC and YA (GH: 34.8 +/- 1.9 vs 2.8 +/- 0.4 vs 1.4 +/- 0.4 mu g/l,p <0.0006; ICE-I: 36.3 +/- 1.9 vs 152.0 +/- 11.5 vs 175.8 +/- 15.3 mu g/l, p <0.0007); in the last two groups GH and ICE-I levels were similar, The mean delta GB peak after HEX in NE (32.8 +/- 4.7 mu g/l) was similar to that in PC (34.6 +/- 4.3 mu g/l) and lower (p <0.01) than thatin YA (56.2 +/- 7.4 mu g/l). Delta GH peak after GHRH in NE (60.1 +/-1.5) was higher than those in PC and YA (20.8 +/- 4.8 and 22.8 +/- 3.4 mu g/l) (p <0.005 and <0.002, respectively), In NE, the GH response to HEX was lower (p<0.005) than to GHRH while ire PC and YA the somatotrope response to HEX was higher (p <0.03 and 0.0004, respectively) than to GHRH, These data demonstrate that the CH-releasing effect of Hexarelin undergoes age-dependent variation being lower in newborns than in young adults, opposite to that observed after GHRH administration, The evidence that Hexarelin releases less CH than GHRH in newborns butnot in prepubertal children and in young adults makes unlikely the hypothesis that the CH-releasing effect of this hexapeptide is mediated via endogenous GHRH release.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 06:06:52