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Titolo:
POTENTIATION OF DEVELOPING SYNAPSES BY POSTSYNAPTIC RELEASE OF NEUROTROPHIN-4
Autore:
WANG XH; POO MM;
Indirizzi:
UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093 UNIV CALIF SAN DIEGO,DEPT BIOL LA JOLLA CA 92093
Titolo Testata:
Neuron
fascicolo: 4, volume: 19, anno: 1997,
pagine: 825 - 835
SICI:
0896-6273(1997)19:4<825:PODSBP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; DEVELOPING NEUROMUSCULAR SYNAPSES; NICOTINIC ACETYLCHOLINE-RECEPTOR; CULTURED HIPPOCAMPAL-NEURONS; LONG-TERM POTENTIATION; KITTEN VISUAL-CORTEX; GENE-RELATED PEPTIDE; SYNAPTIC TRANSMISSION; CORTICAL-NEURONS; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
X.H. Wang e M.M. Poo, "POTENTIATION OF DEVELOPING SYNAPSES BY POSTSYNAPTIC RELEASE OF NEUROTROPHIN-4", Neuron, 19(4), 1997, pp. 825-835

Abstract

The hypothesis that synaptic functions can be regulated by neurotrophins secreted from the postsynaptic cell was examined in Xenopus nerve-muscle cultures. Neuromuscular synapses formed on myocytes overexpressing neurotrophin-4 (M+ synapses) exhibited a higher level of spontaneous synaptic activity and enhanced evoked synaptic transmission as compared to those formed on normal control myocytes (M- synapses). The NT-4 effects involve a potentiation of presynaptic transmitter secretion as well as a lengthening of the mean burst duration of postsynaptic low conductance acetylcholine channels. Repetitive stimulation of eitherthe presynaptic neuron or the postsynaptic myocyte led to a potentiation of synaptic transmission at M+ synapses. All potentiation effects of NT-4 overexpression were abolished by the extracellular presence ofTrkB-IgG but not by the presence of TrkA-IgG, indicating that postsynaptic secretion of NT-4 was responsible for the synaptic modification.

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Documento generato il 02/04/20 alle ore 19:03:42