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Titolo:
ALTERED GENE-EXPRESSION IN SKIN MELANOMAS IS CORRELATED WITH THE LEVEL OF SKIN INFILTRATION AND METASTATIC SPREADING
Autore:
TREVISAN G; SCLAUNICH S; BONIN S; STANTA G;
Indirizzi:
OSPED CATTINARA,DEPT DERMATOL,STR FIUME I-34149 TRIESTE ITALY UNIV TRIESTE,DEPT DERMATOL TRIESTE ITALY UNIV TRIESTE,DEPT PATHOL TRIESTE ITALY INT CTR GENET ENGN & BIOTECHNOL TRIESTE ITALY
Titolo Testata:
JEADV. Journal of the European Academy of Dermatology and Venereology
fascicolo: 1, volume: 9, anno: 1997,
pagine: 57 - 61
SICI:
0926-9959(1997)9:1<57:AGISMI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOCLONAL-ANTIBODIES; AMPLIFICATION; INHIBITION; GROWTH; RECEPTOR; RELAPSE; CANCERS; BREAST;
Keywords:
SKIN MELANOMA; BRESLOW STAGE; RECURRENCE; EGF-RECEPTOR; C-ERBB2; MTS1; RT-PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
G. Trevisan et al., "ALTERED GENE-EXPRESSION IN SKIN MELANOMAS IS CORRELATED WITH THE LEVEL OF SKIN INFILTRATION AND METASTATIC SPREADING", JEADV. Journal of the European Academy of Dermatology and Venereology, 9(1), 1997, pp. 57-61

Abstract

Background In many tumors and also in melanomas a high expression of different growth factor receptors is sometimes present, and epidermal growth factor receptor (EGFr) and oncogene c-erbB2 are often involved. Recently a tumor suppressor gene, called MTS1, has been identified. MTS1 may have an important function in many tumors like those of the lung, breast, bone, ovary and skin melanomas. Objectives In our study weanalyzed the expression at mRNA level of EGFr, c-erbB2 and MTS1 in biopsied paraffin-embedded tissues of skin melanomas at different stagesof Breslow and according to the presence or absence of metastatic spreading during follow-up. Methods The relative quantitation of the mRNAwas performed from histological sections cut from formalin-fixed and paraffin-embedded tissues after RT-PCR. Eighteen patients with melanoma were studied at mRNA expression level of EGF-receptor, c-erbB2, oncogene and MTS1 tumor suppressor gene. The expression has been correlated with the Breslow stage of skin infiltration and the presence of recurrences during the follow-up period. Results The level of expression of EGFr was connected with the level of skin infiltration; in Breslow stages 1 and 2 the expression is low and clearly higher in Breslow 3. But a higher expression is not directly correlated with the presence ofrecurrences. On the other hand higher levels of c-erbB2 and MTS1 mRNAare related, particularly in stage 3 of skin infiltration melanomas, with absence of recurrences. In this case c-erbB2 seems to be a variable independent of Breslow stage. Conclusions Our study suggests in a preliminary way that a high level of expression of c-erbB2 or MTS1 could be connected with infiltrative melanomas, Breslow stage 3, that do not tend to cause recurrences. On the other hand the EGFr expression isrelated to the stage of the skin infiltration of the tumors. (C) 1997Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:53:10