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Titolo:
POTENTIATION OF THE CYTOTOXICITY OF CARBOQUONE BY FLAVONE ACETIC-ACIDCOMBINED WITH HYPERTHERMIA
Autore:
TAKEUCHI H; BABA H; INUTSUKA S; MAEHARA Y; SUGIMACHI K;
Indirizzi:
KYUSHU UNIV HOSP,CTR CANC,HIGASHI KU,MAIDASHI 3-1-1 FUKUOKA 812 JAPAN KYUSHU UNIV,FAC MED,DEPT SURG 2,HIGASHI KU FUKUOKA 812 JAPAN
Titolo Testata:
Anti-cancer drugs
fascicolo: 8, volume: 8, anno: 1997,
pagine: 778 - 783
SICI:
0959-4973(1997)8:8<778:POTCOC>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
WHOLE-BODY HYPERTHERMIA; TUMOR-NECROSIS-FACTOR; MITOMYCIN-C; PHASE-I; ANTICANCER DRUGS; CELLS INVITRO; BLOOD-FLOW; AGENTS; MALIGNANCIES; RADIATION;
Keywords:
FLAVONE ACETIC ACID; CARBOQUONE; HYPERTHERMIA; TUMOR BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
H. Takeuchi et al., "POTENTIATION OF THE CYTOTOXICITY OF CARBOQUONE BY FLAVONE ACETIC-ACIDCOMBINED WITH HYPERTHERMIA", Anti-cancer drugs, 8(8), 1997, pp. 778-783

Abstract

Flavone acetic acid (FAA) has shown the effectiveness of vasoactive drugs in the selective reduction of tumor blood flow. A FAA-mediated decrease in tumor blood flow may produce sufficient hypoxic conditions within the tumor. Carboquone (cc), a naturally occurring prototype bioreductive alkylating agent like mitomycin C (MMC), has been shown to beselectively more cytotoxic toward hypoxic tumor cells. We have reported enhancement of the combined antitumor effects of MMC plus FAA and hyperthermia (HT). In this study, we examined the combined effects of FAA, Cc and HT. In vitro, although HT (43 degrees C, 60 min) reduced the colonogenicity to 0.58 in cc (0.01 mu g/ml) alone, the combined cytotoxicity of Cc and HT was not enhanced with exposure to FAA at a concentration of 100 mu g/ml. In vivo, the tumor growth time, calculated asthe time required to reach twice the initial tumor volume, for cc (2 mg/kg) alone, FAA (150 mg/kg) alone, CQ+FAA, CQ+HT (43 degrees C, 15 min), FAA+HT and FAA+CQ+HT was 6.1, 5.1, 7.1, 8.0, 7.6 and 13.4 days, respectively. A significant enhancement of antitumor effects by trimodality therapy with cc, FAA and HT was observed, when compared to the treatment with cc and FAA (p < 0.05). The possible mechanisms of an increased antitumor response achieved with the combination of cc, FAA and HT may be explained in the following way: the FAA-mediated decrease intumor blood flow produced sufficient hypoxic conditions within the tumor, and these resulted in a significant increase of the antitumor effects of Cc and HT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:19:10