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Titolo:
EFFECTS OF A NITRIC-OXIDE SYNTHASE INHIBITOR ON NMDA RECEPTOR FUNCTION IN ORGANOTYPIC HIPPOCAMPAL CULTURES
Autore:
MUSLEH W; YAGHOUBI S; BAUDRY M;
Indirizzi:
UNIV SO CALIF,HNB 309,PROGRAM NEUROSCI LOS ANGELES CA 90089 UNIV SO CALIF,HNB 309,PROGRAM NEUROSCI LOS ANGELES CA 90089
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 770, anno: 1997,
pagine: 298 - 301
SICI:
0006-8993(1997)770:1-2<298:EOANSI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; RAT-BRAIN; INDUCTION; STIMULATION; DEPRESSION; LTP;
Keywords:
NITRIC OXIDE; N-METHYL-D-ASPARTATE; SPECTRIN; LONG-TERM POTENTIATION; SLICE CULTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
W. Musleh et al., "EFFECTS OF A NITRIC-OXIDE SYNTHASE INHIBITOR ON NMDA RECEPTOR FUNCTION IN ORGANOTYPIC HIPPOCAMPAL CULTURES", Brain research, 770(1-2), 1997, pp. 298-301

Abstract

Nitric oxide (NO) has been proposed to trigger long-term potentiation(LTP) at CA3 to CA1 synapses. We previously reported that NO synthesis inhibitors and blockers reduce an electrophysiological index of NMDAreceptor activation in acute hippocampal slices. We now show that theNOS inhibitor, N-G-methyl-L-arginine (MLA), also reversibly prevents LTP induction in organotypic hippocampal slices and significantly reduces a biochemical index of NMDA receptor function. These results further indicate that MLA inhibits LTP induction by interfering with NMDA receptor functions. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:50:12