Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EARLY DETECTION OF PNEUMONIA IN FEBRILE NEUTROPENIC PATIENTS - USE OFTHIN-SECTION CT
Autore:
HEUSSEL CP; KAUCZOR HU; HEUSSEL G; FISCHER B; MILDENBERGER P; THELEN M;
Indirizzi:
UNIV MAINZ,DEPT RADIOL,LANGENBECKSTR 1 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT HEMATOL D-55131 MAINZ GERMANY UNIV MAINZ,DEPT PNEUMOL D-55131 MAINZ GERMANY
Titolo Testata:
American journal of roentgenology
fascicolo: 5, volume: 169, anno: 1997,
pagine: 1347 - 1353
SICI:
0361-803X(1997)169:5<1347:EDOPIF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
INVASIVE PULMONARY ASPERGILLOSIS; INFILTRATIVE LUNG-DISEASE; EARLY DIAGNOSIS; ORGANIZING PNEUMONIA; ACUTE-LEUKEMIA; RISK-FACTORS; COMPLICATIONS; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
C.P. Heussel et al., "EARLY DETECTION OF PNEUMONIA IN FEBRILE NEUTROPENIC PATIENTS - USE OFTHIN-SECTION CT", American journal of roentgenology, 169(5), 1997, pp. 1347-1353

Abstract

OBJECTIVE. The purpose of this study was to evaluate the usefulness of thin-section CT for early detection of pneumonia in neutropenic patients with an unknown site of infection and normal or nonspecific findings on chest radiographs.SUBJECTS AND METHODS. Eighty-seven patients with febrile neutropenia that persisted for more than 2 days despite empiric antibiotic treatment underwent 146 prospective examinations. If findings on chest radiographs were normal (n = 126) or nonspecific (n = 20), thin-section CT (1-mm collimation, 10-mm increment) was done. If thin-section CT scans showed opacities, bronchoalveolar lavage was recommended. RESULTS. Findings on chest radiographs were nonspecific for pneumonia in 20 (14%) of 146 cases, and CT findings in those cases were suggestive of pneumonia. Microorganisms were detected in Il of those 20 cases. Seven of the 11 cases were not optimally treated before CT diagnosis, the other four were sufficiently treated. Findings on chest radiographs and thin-section CT scans were normal in 56 (38%) of 146 cases. In 70 (48%) of 146 cases, findings on chest radiographs were normal, whereas findings on thin-section CT scans were suggestive of pneumonia. Microorganisms were detected in 30 of the 70 cases. Nineteenof 30 cases were not optimally treated before CT, whereas the other 11 cases were sufficiently treated before CT. In 22 (31%) of these 70 cases, an opacity was observed on the chest radiograph during the 7 days after the CT study. Only three (5%) of 56 pneumonias occurred duringthe first 7 days after thin-section CT studies with normal findings (p < .005). Additional risk factors for pneumonia occurring later that were detectable on chest radiographs were poorly defined nodules (p < .05), consolidation (p < .05), and younger age (p < .05). CONCLUSION. Thin-section CT scans show findings suggestive of pneumonia about 5 days earlier than chest radiographs show suggestive findings. When thin-section CT scans show findings suggestive of pneumonia, the probability of pneumonia being detected on chest radiographs during the 7-day follow-up is 31%, whereas the probability is only 5% when the findings on the prior thin-section CT scan were normal (p < .005). All neutropenic patients with fever of unknown origin and normal findings on chest radiographs should be examined with thin-section CT.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 06:57:34