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Titolo:
BRAIN NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN CENTRAL MINERALOCORTICOID HYPERTENSION
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; FURUKAWA K; INABA S; TAKEDA R; MABUCHI H;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2,13-1 TAKARA MACHI KANAZAWA ISHIKAWA 920 JAPAN KANAZAWA UNIV,SCH MED,DEPT HLTH SCI KANAZAWA ISHIKAWA 920 JAPAN KKR HOKURIKU HOSP KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Hypertension
fascicolo: 4, volume: 30, anno: 1997,
pagine: 953 - 956
SICI:
0194-911X(1997)30:4<953:BNSMIC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSTERONE-PRODUCING ADENOMA; SYMPATHETIC-NERVE ACTIVITY; L-ARGININE; GENE-EXPRESSION; BLOOD-PRESSURE; RAT-BRAIN; 19-NORALDOSTERONE; 18-HYDROXY-19-NORCORTICOSTERONE; 18,19-DIHYDROXYCORTICOSTERONE; 19-NOR-ALDOSTERONE;
Keywords:
MINERALOCORTICOID; RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ALDOSTERONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "BRAIN NITRIC-OXIDE SYNTHASE MESSENGER-RNA IN CENTRAL MINERALOCORTICOID HYPERTENSION", Hypertension, 30(4), 1997, pp. 953-956

Abstract

The mechanism underlying the central hypertensinogenic effects of mineralocorticoids remains unclear. Given that nitric oxide (NO) is thought to act at autonomic sites in the brain to regulate arterial blood pressure, the effects of the potent mineralocorticoids aldosterone and 19-noraldosterone on the abundance of neuronal NO synthase (nNOS) mRNAin the brain were investigated. Wistar-Kyoto rats received a continuous intracerebroventricular infusion of aldosterone or 19-noraldosterone (5 ng/h) from an implanted osmotic minipump for 4 weeks. Total RNA was purified from microdissected tissue blocks containing the hypothalamus, dorsal medulla, rostral ventrolateral medulla, or caudal ventrolateral medulla, and changes in the abundance of nNOS mRNA were determined with a semiquantitative competitive polymerase chain reaction method. Blood pressure was significantly increased in rats 2, 3, and 4 weeks after the onset of intracerebroventricular aldosterone or 19-noraldosterone infusion compared with that in animals receiving vehicle. Subcutaneous infusion of either mineralocorticoid had no effect on blood pressure. Compared with controls, rats treated with aldosterone or 19-noraldosterone for 4 weeks showed significant decreases in the amount of nNOS mRNA in the hypothalamus and rostral and caudal ventrolateral medulla. These data suggest that reduced nNOS activity may contribute to the increase in blood pressure in rats with central mineralocorticoid-induced hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:07:07