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Titolo:
GENETIC ISOLATION OF A CHROMOSOME-1 REGION AFFECTING BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
Autore:
STLEZIN E; LIU WZ; WANG JM; WANG N; KREN V; KRENOVA D; MUSILOVA A; ZDOBINSKA M; ZIDEK V; LAU D; PRAVENEC M;
Indirizzi:
ACAD SCI CZECH REPUBL,INST PHYSIOL,VIDENSKA 1083 CR-14220 PRAGUE 4 CZECH REPUBLIC ACAD SCI CZECH REPUBL,INST PHYSIOL CR-14220 PRAGUE 4 CZECH REPUBLIC UNIV CALIF SAN FRANCISCO,DEPT LAB MED SAN FRANCISCO CA 94143 UNIV CALIF SAN FRANCISCO,ANIM CARE FACIL SAN FRANCISCO CA 94143 CHARLES UNIV,INST BIOL,FAC MED 1 PRAGUE CZECH REPUBLIC ACAD SCI CZECH REPUBL,INST PHYSIOL PRAGUE CZECH REPUBLIC
Titolo Testata:
Hypertension
fascicolo: 4, volume: 30, anno: 1997,
pagine: 854 - 858
SICI:
0194-911X(1997)30:4<854:GIOACR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT INBRED STRAINS; QUANTITATIVE TRAIT LOCI; LINKAGE MAP; SA-GENE; CONGENIC STRAIN; RENIN GENE; COSEGREGATION; MARKERS;
Keywords:
HYPERTENSION, GENETIC; CONGENIC STRAIN; TRAIT LOCUS; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
E. Stlezin et al., "GENETIC ISOLATION OF A CHROMOSOME-1 REGION AFFECTING BLOOD-PRESSURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT", Hypertension, 30(4), 1997, pp. 854-858

Abstract

Recent linkage studies in the spontaneously hypertensive rat (SHR) suggest that a blood pressure regulatory gene or genes may be located onrat chromosome 1q. To investigate this possibility, we replaced a region of chromosome 1 in the SHR (defined by the markers D1Mit3 and Igf2) with the corresponding chromosome segment from the normotensive Brown-Norway (BN) strain. In male SHR congenic rats carrying the transferred BN chromosome segment, 24-hour average systolic and diastolic bloodpressures were significantly lower than in male progenitor SHR. Polymerase chain reaction genotyping using 60 polymorphic microsatellite markers dispersed throughout the genome confirmed the congenic status ofthe new strain designated SHR.BN-D1Mit3/Igf2. These findings provide direct evidence that a blood pressure regulatory gene exists on the differential segment of chromosome 1 that is sufficient to decrease blood pressure in the SHR. The SHR.BN-D1Mit3/Igf2 congenic strain represents an important new model for fine mapping and characterization of genes on chromosome 1 involved in the pathogenesis of spontaneous hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:33:21