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Titolo:
MODERATELY OBESE, INSULIN-RESISTANT WOMEN EXHIBIT ABNORMAL VASCULAR REACTIVITY TO STRESS
Autore:
SUNG BH; WILSON MF; IZZO JL; RAMIREZ L; DANDONA P;
Indirizzi:
SUNY BUFFALO,MILLARD FILLMORE HOSP,DEPT MED,3 GATES CIRCLE BUFFALO NY14209 MILLARD FILLMORE HLTH SYST BUFFALO NY 14209
Titolo Testata:
Hypertension
fascicolo: 4, volume: 30, anno: 1997,
pagine: 848 - 853
SICI:
0194-911X(1997)30:4<848:MOIWEA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-PRESSURE; MENTAL STRESS; ACCELERATED ATHEROSCLEROSIS; HYPERTENSION; HYPERINSULINEMIA; NOREPINEPHRINE; EXERCISE; DISEASE; HEALTHY;
Keywords:
INSULIN RESISTANCE; VASCULAR RESISTANCE; BLOOD PRESSURE; STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
B.H. Sung et al., "MODERATELY OBESE, INSULIN-RESISTANT WOMEN EXHIBIT ABNORMAL VASCULAR REACTIVITY TO STRESS", Hypertension, 30(4), 1997, pp. 848-853

Abstract

To define the hemodynamic implications of insulin resistance (IR), wecompared 10 normotensive, insulin-resistant women who had abnormal glucose tolerance tests with 10 age-matched healthy normotensive women with normal glucose tolerance tests with respect to mental arithmetic and handgrip responses. Hemodynamic variables obtained at baseline and during stress included heart rate, blood pressure, cardiac output, andsystemic vascular resistance. The IR group weighed more (84 versus 66kg). Screening BP was similar (123/72 versus 120/68 mmHg, P=NS) between groups although baseline diastolic BP at testing day was higher in the IR group than control group (75 versus 65 mm Hg, P<.05). The IR group showed a significantly greater increase in systolic (18% versus 10%, P<.01) and diastolic (24% versus 12%, P<.01) blood pressure responses to mental stress than the control group. During mental stress, the control group demonstrated increased cardiac output (1.4 L/min) and decreased systemic vascular resistance (-120 dyne.s.cm(-5)), whereas IR subjects demonstrated increased systemic vascular resistance (119 dyne.s.cm(-5); group difference, P<.02) with only a small increase in cardiac output (0.5 L/min). Handgrip also caused a greater increase in systemic vascular resistance in the IR group (252 versus 64 dyne.s.cm(-5), P<.05), with a correspondingly greater increase in blood pressure than control subjects. Baseline blood pressure was correlated with weight (r=.41, P<.02) and stress blood pressure with fasting insulin (r=.51, P<.001) and glucose-to-insulin ratio (r=-.55, P<.001). We conclude that insulin resistance is associated with an exaggerated blood pressure response to stress; art enhanced vasoconstriction to stress may mediate this response. This hyperreactivity may be a marker for future hypertension in obese, normotensive, hyperinsulinemic individuals.

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Documento generato il 23/10/20 alle ore 10:57:46