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Titolo:
BROAD-BAND SPECTRAL-ANALYSIS OF BLOOD-PRESSURE AND HEART-RATE-VARIABILITY IN VERY ELDERLY SUBJECTS
Autore:
PARATI G; FRATTOLA A; DIRIENZO M; CASTIGLIONI P; MANCIA G;
Indirizzi:
UNIV MILAN,CTR FISIOL CLIN & IPERTENS,VIA F SFORZA 35 I-20122 MILAN ITALY OSPED MAGGIORE I-20122 MILAN ITALY UNIV MILAN,OSPED S GERARDO,CATTEDRA MED INTERNA 1 I-20122 MILAN ITALY IST SCI OSPED S LUCA,IST AUXOL ITALIANO MILAN ITALY FDN PRO JUVENTUTE,CTR BIOINGN,LARC MILAN ITALY
Titolo Testata:
Hypertension
fascicolo: 4, volume: 30, anno: 1997,
pagine: 803 - 808
SICI:
0194-911X(1997)30:4<803:BSOBAH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULSE-INTERVAL; UNANESTHETIZED CATS; HYPERTENSION; HUMANS; FINGER; AGE;
Keywords:
AGING; BROAD-BAND SPECTRAL ANALYSIS; BLOOD PRESSURE; HEART RATE; BAROREFLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
G. Parati et al., "BROAD-BAND SPECTRAL-ANALYSIS OF BLOOD-PRESSURE AND HEART-RATE-VARIABILITY IN VERY ELDERLY SUBJECTS", Hypertension, 30(4), 1997, pp. 803-808

Abstract

Systolic blood pressure (SEP) variability is increased and R-R interval variability is reduced in the elderly. Little is known, however, about how SEP and R-R interval variabilities change in the very elderly. More important, however, it is not known which frequency components of SEP and R-R interval variability are affected significantly. We addressed this issue in subjects older than 70 years by broadband spectralanalysis, which allows all variability components from the lowest to the highest frequency to be considered. In 20 very elderly normotensive subjects (mean+/-SD age, 78.1+/-6.8 years) and 28 normotensive adultsubjects (36.1+/-7.1 years), noninvasive finger blood pressure and R-R intervals were recorded continuously for 30 minutes in the supine position and 15 minutes in the upright position. SEP and R-R interval power spectral densities were computed over the entire frequency region between 0.005 Hz (0.007 Hz in the upright position) and 0.5 Hz. Overall SEP variability (SD) was greater and overall R-R interval variability was less in very old subjects than in adult subjects. All spectral R-R interval powers were reduced significantly in very elderly individuals. The spectral SEP powers were greater in the very elderly group than in the adult group only in the very-low-frequency range (<0.04 Hz). This was true in the supine and the standing positions. With subjectsin the standing position, the shape of the broadband spectra differedin the very old and adult subjects because in the former group the increase in SEP and R-R interval power around 0.1 Hz that was seen in the latter was blunted. Therefore, in very elderly subjects a reduction in overall R-R interval variability is accounted for by a reduction inall of its frequency components. The accompanying increase in overallBP variability, however, results from a nonhomogeneous behavior of its frequency components, which consists of an increase in the very low frequency and a concomitant reduction in the higher frequency powers. The mechanisms responsible for these changes may be complex, but at least they may in part reflect the baroreflex impairment and autonomic dysfunction that characterize aging.

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Documento generato il 04/12/20 alle ore 01:23:09