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Titolo:
ACTIVATION OF CENTRAL 5HT1B RECEPTORS INCREASES LOCOMOTOR-ACTIVITY INMICE
Autore:
ONEILL MF; FERNANDEZ AG; PALACIOS JM;
Indirizzi:
LILLY RES CTR LTD,ERI WOOD MANOR,SUNNINGHILL RD WINDLESHAM GU20 6PH SURREY ENGLAND LABS ALMIRALL SA,RES CTR BARCELONA 08024 SPAIN
Titolo Testata:
Human psychopharmacology
fascicolo: 5, volume: 12, anno: 1997,
pagine: 431 - 435
SICI:
0885-6222(1997)12:5<431:AOC5RI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGONIST; RELEASE; POTENT; RATS;
Keywords:
ANPIRTOLINE; S-CM-GTNH2; LOCOMOTION; 5HT-1B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
M.F. Oneill et al., "ACTIVATION OF CENTRAL 5HT1B RECEPTORS INCREASES LOCOMOTOR-ACTIVITY INMICE", Human psychopharmacology, 12(5), 1997, pp. 431-435

Abstract

The effects of 5-HT1B/D receptor agonists anpirtoline, S-CM-GTNH2 andCP93129 were examined in locomotor activity tests in mice. Anpirtoline and S-CM-GTNH2 both significantly increased locomotor activity (ambulation) (minimum affective doses; 3 and 30 mg/kg respectively). CP93129 injected subcutaneously was without effect, but increased locomotor activity when given i.c.v. Thus activation of central 5-HT1B receptorsresults in increased locomotor activity. The effects of anpirtoline and S-CM-GTNH2 were blocked by the antagonist GR 127935 suggesting thatGR 127935 is an effective antagonist of 5-HT1B receptors in vivo. (C)1997 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 05:01:48