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Titolo:
MEDICINAL FOODSTUFFS .9. THE INHIBITORS OF GLUCOSE-ABSORPTION FROM THE LEAVES OF GYMNEMA-SYLVESTRE R. BR. (ASCLEPIADACEAE) - STRUCTURES OF GYMNEMOSIDE-A AND GYMNEMOSIDE-B
Autore:
YOSHIKAWA M; MURAKAMI T; KADOYA M; LI YH; MURAKAMI N; YAMAHARA J; MATSUDA H;
Indirizzi:
KYOTO PHARMACEUT UNIV,YAMASHIMA KU,5 NAKAUCHI CHO KYOTO 607 JAPAN JAPAN & RES INST PROD DEV,SAKYO KU KYOTO 606 JAPAN
Titolo Testata:
Chemical and Pharmaceutical Bulletin
fascicolo: 10, volume: 45, anno: 1997,
pagine: 1671 - 1676
SICI:
0009-2363(1997)45:10<1671:MF.TIO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARALIA-ELATA SEEM; PAIRWISE MULTIPLE COMPARISONS; CHINESE NATURAL MEDICINES; CAMELLIA-JAPONICA L; Z-SENEGIN-III; BIOACTIVE SAPONINS; ETHANOL ABSORPTION; HYPOGLYCEMIC ACTIVITY; ABSOLUTE STEREOSTRUCTURES; ANTISWEET PRINCIPLES;
Keywords:
GYMNEMA SYLVESTRE; GYMNEMOSIDE; GLUCOSE ABSORPTION INHIBITOR; ACYL MIGRATION; TRITERPENE GLYCOSIDE; ORAL GLUCOSE-LOADED TEST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
M. Yoshikawa et al., "MEDICINAL FOODSTUFFS .9. THE INHIBITORS OF GLUCOSE-ABSORPTION FROM THE LEAVES OF GYMNEMA-SYLVESTRE R. BR. (ASCLEPIADACEAE) - STRUCTURES OF GYMNEMOSIDE-A AND GYMNEMOSIDE-B", Chemical and Pharmaceutical Bulletin, 45(10), 1997, pp. 1671-1676

Abstract

Although the glycosidic fraction from the dried leaves of Gymnema sylvestre R. BR., gymnemic acid, was reported to be effective for diabetes, it showed little inhibitory activity on the increase of serum glucose level in oral glucose-loaded rats. From the glycosidic fraction, six triterpene glycosides, gymnemosides a, b, c, d, e, and f, were isolated together with nine known triterpene glycosides. The structures of gymnemosides a and b were determined on the basis of chemical and physicochemical evidence as 21-O-tigloyl-22-O-acetylgymnemagenin 3-O-beta-D-glucopyranosiduronic acid and 16-O-acetyl-21-O-tigloylgymnemagenin 3-O-beta-D-glucopyranosiduronic acid, respectively. In addition, an acetyl group linked to the 16- or 22-hydroxyl group in gymnemosides a andb was found to migrate easily to the primary 28-hydroxyl group, whilethe acyl migration from the 28-position was rarely observed. The inhibitory activity of each triterpene glycoside from gymnemic acid was examined to determine its impact on the increase of serum glucose level in oral glucose-loaded rats. Gymnemoside b and gymnemic acids III, V, and VII were found to exhibit a little inhibitory activity against glucose absorption, but the principal constituents, gymnemic acid I and gymnemasaponin V, lacked this activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 10:12:00