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Titolo:
LACK OF ASSOCIATION OF ANGIOTENSIN-II TYPE-1 RECEPTOR GENE POLYMORPHISM WITH DIABETIC NEPHROPATHY IN INSULIN-DEPENDENT DIABETES-MELLITUS
Autore:
CHOWDHURY TA; DYER PH; KUMAR S; GOUGH SCL; GIBSON SP; ROWE BR; SMITH PR; DRONSFIELD MJ; MARSHALL SM; MACKIN P; DEAN JD; MORRIS PJ; DAVIES S; DUNGER DB; BOULTON AJM; BARNETT AH; BAIN SC;
Indirizzi:
BIRMINGHAM HEARTLANDS HOSP,CTR DIABET,DEPT MED,WARD 24,BORDESLEY GREEN E BIRMINGHAM B9 5SS W MIDLANDS ENGLAND
Titolo Testata:
Diabetic medicine
fascicolo: 10, volume: 14, anno: 1997,
pagine: 837 - 840
SICI:
0742-3071(1997)14:10<837:LOAOAT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PREDICTIVE VALUE; HYPERTENSION; IDDM; MICROALBUMINURIA; RISK;
Keywords:
ANGIOTENSIN II TYPE 1 RECEPTOR; GENE POLYMORPHISM; NEPHROPATHY; IDDM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Chowdhury et al., "LACK OF ASSOCIATION OF ANGIOTENSIN-II TYPE-1 RECEPTOR GENE POLYMORPHISM WITH DIABETIC NEPHROPATHY IN INSULIN-DEPENDENT DIABETES-MELLITUS", Diabetic medicine, 14(10), 1997, pp. 837-840

Abstract

Several observations suggest that inherited factors are influential in the development of nephropathy in patients with insulin-dependent diabetes mellitus (IDDM). Genetic components of the renin angiotensin system are possible candidate genes. The aim of this study was to determine the role of the hypertension associated angiotensin II type 1 receptor (AT1R) gene A(1166)C polymorphism in susceptibility to nephropathy in IDDM. We examined 264 Caucasoid patients with IDDM and overt nephropathy (as defined by persistent proteinuria in the absence of other causes, hypertension and retinopathy), 136 IDDM patients with long duration of diabetes and no nephropathy (LDNN group), 200 recently diagnosed IDDM patients (Sporadic Diabetic group), and 212 non-diabetic subjects. The AT1R gene polymorphism was assessed using the polymerase chain reaction and restriction isotyping. Genotype frequencies did not differ significantly between the sporadic diabetic group and the nephropathy group (p = 0.245), nor between the long duration non-nephropathy group and the nephropathy group (p = 0.250). Allele frequencies were not significantly different between the three groups (p = 0.753). We conclude that there is no significant association between the hypertension associated AT1R gene polymorphism and diabetic nephropathy in patients with IDDM in the UK. (C) 1997 by John Wiley & Sons, Ltd.

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Documento generato il 23/11/20 alle ore 20:17:45