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Titolo:
EXPOSURE TO A CONDITIONED AVERSIVE ENVIRONMENT INTERFERES WITH LONG-TERM POTENTIATION INDUCTION IN THE FIMBRIA-CA3 PATHWAY
Autore:
GARCIA R; TOCCO G; BAUDRY M; THOMPSON RF;
Indirizzi:
UNIV BORDEAUX 1,LAB NEUROSCI COMPORTEMENTALES & COGNIT,CNRS,URA 339 F-33405 TALENCE FRANCE UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 82, anno: 1998,
pagine: 139 - 145
SICI:
0306-4522(1998)82:1<139:ETACAE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMED BURST POTENTIATION; CONTEXTUAL FEAR; RATS; HIPPOCAMPUS; AMNESIA; LESIONS; LTP; AMYGDALA;
Keywords:
CONDITIONED AVERSIVE ENVIRONMENT; LONG-TERM POTENTIATION; FIMBRIA; HIPPOCAMPUS; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R. Garcia et al., "EXPOSURE TO A CONDITIONED AVERSIVE ENVIRONMENT INTERFERES WITH LONG-TERM POTENTIATION INDUCTION IN THE FIMBRIA-CA3 PATHWAY", Neuroscience, 82(1), 1998, pp. 139-145

Abstract

The effect of re-exposure of rats to an aversive environment on the induction of long-term potentiation was investigated in the CA3 region 3 and 12 h after contextual conditioning. Electrophysiological recordings showed that re-exposure of rats to the conditioning chamber produced a significant and long-lasting decrease in population spike amplitude al both post-conditioning delays. High-frequency stimulation of thefimbria induced a large and persistent increase in CA3 population spike amplitude (about 400% of baseline) in animals of control groups andshocked animals that were not re-exposed to the conditioning environment. However, high-frequency stimulation applied during re-exposure ofshocked subjects 3 h after the initial exposure resulted in a small and transient increase in population spike amplitude (about 140% of baseline); when applied 12 h after the initial exposure, it produced a persistent depression of the response (-30% of baseline). Behavioural testing indicated that re-exposure of shocked animals to the conditioning environment elicited a qualitatively and quantitatively similar freezing behaviour al both post-conditioning delays (3 or 12 h). In contrast to the long-lasting decrease in CA3 population spike amplitude produced by re-exposure to the aversive environment, the level of freezingbehaviour diminished rapidly within 10 min of exposure. These resultssuggest that, during exposure to a conditioned aversive environment, alterations in fimbria-CA3 neural processing may be dissociated from contextual fear-induced freezing behaviour. In addition, processes underlying long-term potentiation induction in fimbria-CA3 pathway may be opposite to those taking place during hippocampal processing of conditioned aversive contexts. (C) 1997 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 20/01/21 alle ore 12:12:55