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Titolo:
BINDING AND BIOLOGICAL-ACTIVITY OF C-TERMINALLY MODIFIED MELANOCORTINPEPTIDES - A COMPARISON BETWEEN THEIR ACTIONS AT RODENT MC1 AND MC3 RECEPTORS
Autore:
PENG PJ; SAHM UG; DOHERTY RVM; KINSMAN RG; MOSS SH; POUTON CW;
Indirizzi:
INSERM 1,CTR PAUL BROCA,UNITE NEUROBIOL & PHARMACOL,2TER RUE ALESIA F-75014 PARIS FRANCE UNIV BATH,SCH PHARM & PHARMACOL BATH BA2 7AY AVON ENGLAND UNIV BATH,SCH CHEM BATH BA2 7AY AVON ENGLAND
Titolo Testata:
Peptides
fascicolo: 7, volume: 18, anno: 1997,
pagine: 1001 - 1008
SICI:
0196-9781(1997)18:7<1001:BABOCM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; BETA-LIPOTROPIN PRECURSOR; ALPHA-MSH ANALOGS; MOLECULAR-CLONING; MELANOTROPIN; POTENT; RAT; HYPOTHALAMUS; EXPRESSION; ALANINE;
Keywords:
ALPHA-MSH; GAMMA-MSH; MC1 RECEPTOR; MC3 RECEPTOR; BIOLOGICAL ACTIVITY; RECEPTOR BINDING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Peng et al., "BINDING AND BIOLOGICAL-ACTIVITY OF C-TERMINALLY MODIFIED MELANOCORTINPEPTIDES - A COMPARISON BETWEEN THEIR ACTIONS AT RODENT MC1 AND MC3 RECEPTORS", Peptides, 18(7), 1997, pp. 1001-1008

Abstract

Five subtypes of melanocortin receptors have to date been identified,but to dare little is known about the different structural requirements for binding and biological activity at these receptors. In this study, the role of C-terminal melanocortin peptide residues in imparting selectivity for the receptor subtypes was examined. C-terminally modified analogues of alpha-MSH and gamma-MSH were synthesized and their interaction with MC1 and MC3 melanocortin receptors was investigated. This study provides further evidence for an important role of proline 12(numbering with respect to alpha-MSH) for binding and activity at theMC1 receptor. Although the influence of C-terminal amino acids on binding and activity at MC3-R was less marked, some of them were nevertheless observed to be beneficial for the interaction with this receptor subtype. (C) 1997 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:52:55