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Titolo:
IMPAIRED BETA-CELL FUNCTION AND DEPOSITION OF AT DROPLETS IN THE PANCREAS AS A CONSEQUENCE OF HYPERTRIGLYCERIDEMIA IN OLETF RAT, A MODEL OFSPONTANEOUS NIDDM
Autore:
MAN ZW; ZHU M; NOMA Y; TOIDE K; SATO T; ASAHI Y; HIRASHIMA T; MORI S; KAWANO K; MIZUNO A; SANO T; SHIMA K;
Indirizzi:
OTSUKA PHARMACEUT CO LTD,TOKUSHIMA RES INST,463-10 KAGASUNO,KAWAUCHI CHO TOKUSHIMA 77101 JAPAN UNIV TOKUSHIMA,SCH MED,DEPT LAB MED TOKUSHIMA 770 JAPAN UNIV TOKUSHIMA,SCH MED,DEPT PATHOL TOKUSHIMA 770 JAPAN
Titolo Testata:
Diabetes
fascicolo: 11, volume: 46, anno: 1997,
pagine: 1718 - 1724
SICI:
0012-1797(1997)46:11<1718:IBFADO>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOKUSHIMA FATTY RAT; DEPENDENT DIABETES-MELLITUS; INSULIN-RESISTANCE; HYPERGLYCEMIC RAT; GLUCOSE SENSOR; ACID OXIDATION; TRIGLYCERIDE; GLUCOKINASE; METABOLISM; SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
Z.W. Man et al., "IMPAIRED BETA-CELL FUNCTION AND DEPOSITION OF AT DROPLETS IN THE PANCREAS AS A CONSEQUENCE OF HYPERTRIGLYCERIDEMIA IN OLETF RAT, A MODEL OFSPONTANEOUS NIDDM", Diabetes, 46(11), 1997, pp. 1718-1724

Abstract

Hypertriglyceridemia is known to be a feature of obesity-related NIDDM, but the patho-etiological significance of this association is obscure. The effects of triglycerides (TGs) on beta-cell function and morphological changes in pancreas were examined using in vivo and in vitro approaches in male OLETF rats at ages 6, 12, and 30 weeks, with their diabetes-resistant counterpart, LETO rats, as normal controls. The results showed that, in the fasting state, plasma TGs in OLETF rats were increased 2.5-fold at age 6 weeks, 3.3-fold at age 12 weeks, and 6.2-fold at age 30 weeks, compared with age-matched LETO rats. The TG content in islets from 12-week-old OLETF rats was significantly increased when compared with those from their age-matched counterparts, but this was not the case with the 6-week-old OLETF rats. Therefore, the isletsfrom 6-week-old rats were cultured with either free fatty acids (FFAs; 1.0 mmol/l sodium oleate) or TG (5.0 mmol/l Intralipide) for 72 h. Several abnormalities in OLETF rats were evident, in contrast to the results from control LETO rats: 1) glucose-induced insulin secretion wasmore inhibited by either FFAs or TGs in the presence of 27.7 mmol/l glucose, a result associated, at least in part, with reduced glucokinase activity in the islets; 2) a marked elevation in TG content was found in the islets; and 3) the deposition of fat droplets in the enlargedislets, even in the beta-cells, was found by Oil Red O-insulin doublestaining at age 30 weeks. In conclusion, hypertriglyceridemia resulted in significant TG stores in the islets, which subsequently inhibitedglucose-induced insulin secretion, at least in part, via reduced glucokinase activity in the islets. Fat droplets in islets, therefore, mayplay an important role in hastening the development of NIDDM in this rat model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:37:50