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Titolo:
INCREASED EXPRESSION OF CATHEPSIN-D IN RETROSPLENIAL CORTEX OF MK-801-TREATED RATS
Autore:
HETMAN M; DANYSZ W; KACZMAREK L;
Indirizzi:
M NENCKI INST EXPT BIOL,PASTEURA 3 PL-02093 WARSAW POLAND M NENCKI INST EXPT BIOL PL-02093 WARSAW POLAND MERZ & CO,DEPT PHARMACOL D-60318 FRANKFURT GERMANY
Titolo Testata:
Experimental neurology
fascicolo: 2, volume: 147, anno: 1997,
pagine: 229 - 237
SICI:
0014-4886(1997)147:2<229:IEOCIR>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOSOMAL-LYSOSOMAL SYSTEM; ALZHEIMERS-DISEASE; CEREBROCORTICAL NEURONS; POSTERIOR CINGULATE; BRAIN-REGIONS; MK-801; PHENCYCLIDINE; NEUROTOXICITY; LOCALIZATION; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
M. Hetman et al., "INCREASED EXPRESSION OF CATHEPSIN-D IN RETROSPLENIAL CORTEX OF MK-801-TREATED RATS", Experimental neurology, 147(2), 1997, pp. 229-237

Abstract

Single administration of a high dose of an uncompetitive NMDA receptor antagonist-dizocilpine maleate (MK-801)-results in transient neuronal vacuolization and cell death in retrosplenial cortex in rodents. In this study expression of cathepsin D (CatD), a major lysosomal aspartic protease, was investigated in brains of female rats treated with 1, 5, or 10 mg/kg of MK-801. Northern blot analysis demonstrated that theCatD mRNA level was moderately increased in retrosplenial cortex 24 h-7 days after the treatment. Concomitantly, increased CatD immunoreactivity was observed, predominantly in the degenerating neurons in layerIII of retrosplenial cortex. Neuronal response was spatially distinguished from glial reactivation marked by increased mRNA and protein levels of glial fibrillary acidic protein, as demonstrated by Northern blot and immunohistochemistry in retrosplenial cortex 24 h-7 days after MK-801 treatment. These data suggest that activation of the lysosomal proteolytic system of neurons may play a role in MK-801-evoked neurodegeneration. (C) 1997 Academic Press.

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Documento generato il 01/04/20 alle ore 01:42:11