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Titolo:
IDENTIFICATION OF THE METABOLITES OF A NEW OXAZOLIDINONE MAO-A INHIBITOR IN RAT
Autore:
NAITOH T; KAKIKI M; KOZAKI T; MISHIMA M; YUZURIHA T; HORIE T;
Indirizzi:
EISAI & CO LTD,DEPT REGULATORY COMPLIANCE,BUNKYO KU,KOISHIKAWA 4-6-10TOKYO 11288 JAPAN EISAI & CO LTD,TSUKUBA RES LABS TSUKUBA IBARAKI 30026 JAPAN
Titolo Testata:
Xenobiotica
fascicolo: 10, volume: 27, anno: 1997,
pagine: 1071 - 1089
SICI:
0049-8254(1997)27:10<1071:IOTMOA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
E2011;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
T. Naitoh et al., "IDENTIFICATION OF THE METABOLITES OF A NEW OXAZOLIDINONE MAO-A INHIBITOR IN RAT", Xenobiotica, 27(10), 1997, pp. 1071-1089

Abstract

1. Six metabolites present in rat urine after the oral administrationof E2011 enzothiazol-6-yl]-5-methoxymethyl-2-oxazolidinone) mere isolated with an Amberlite XAD-4 column and hplc, and termed HPM-1, HPM-2,HPM-31, HPM-32, HPM-33 and HPM-4. 2. To determine the correspondence of the findings of the metabolites between tie (which was used in our previous study) and hplc, the six metabolites were isolated from rat urine after the administration of C-14-labelled E2011 viith an Amberlite XAD-4 column and hplc, and then analysed by tie. HPM-1, HPM-2, HPM-31, HPM-32, HPM-33 and HPM-4 were identified as IM7, IM3, IM4, IM2, IM1and E2011, respectively. 3. The structures of the metabolites were identified with nmr and mass spectrometry. One of the compounds identified, HPM-4, was the unchanged drug, E2011, and HPM-2 was O-desmethyl-E2011. Another metabolite (HPM-33), the main metabolite in the urine, was identified as (4S)-hydroxy-E2011, and the others were (4S)-hydroxy-O-desmethyl-E2011 (HPM-1), 2 ''-hydroxy-E2011 (HPM-31) and (TR)-hydroxy-E2011 (HPM-32). 4. In conclusion, the main metabolic pathway of E2011in the rat consisted of O-demethylation and hydroxylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:06:54