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Titolo:
EFFECT OF RAMIPRIL ON HEART-RATE-VARIABILITY IN DIGITALIS-TREATED PATIENTS WITH CHRONIC HEART-FAILURE
Autore:
GUEONMOREAU L; PINAUD A; LOGIER R; CARON J; LEKIEFFRE J; DUPUIS B; LIBERSA CH;
Indirizzi:
FAC MED LILLE,SERV PHARMACOL HOSPITALIERE,1 PL DE VERDUN F-59045 LILLE FRANCE HOP CARDIOL,SERV CARDIOL A F-59037 LILLE FRANCE CHR LILLE,INST TECHNOL MED LILLE FRANCE
Titolo Testata:
Cardiovascular drugs and therapy
fascicolo: 4, volume: 11, anno: 1997,
pagine: 531 - 536
SICI:
0920-3206(1997)11:4<531:EOROHI>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVERTING-ENZYME-INHIBITOR; SYMPATHETIC NERVOUS-SYSTEM; CORONARY-ARTERY DISEASE; PLASMA NOREPINEPHRINE; PARASYMPATHETIC ACTIVITY; BARORECEPTOR REFLEX; SPECTRAL-ANALYSIS; ORTHOSTATIC TILT; CARDIAC-FAILURE; NORMAL HUMANS;
Keywords:
ACE INHIBITORS; HEART RATE VARIABILITY; CARDIAC HEART FAILURE; DIGITALIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
L. Gueonmoreau et al., "EFFECT OF RAMIPRIL ON HEART-RATE-VARIABILITY IN DIGITALIS-TREATED PATIENTS WITH CHRONIC HEART-FAILURE", Cardiovascular drugs and therapy, 11(4), 1997, pp. 531-536

Abstract

The aim of this study was to evaluate the effect of an angiotensin-converting enzyme CAGE) inhibitor, ramipril, on heart rate variability in patients with heart failure simultaneously treated with digitalis. This study was a multicentric, randomized, double-blind, placebo-controlled study including 50 patients with chronic heart failure (CBF). Allpatients were in NYHA functional class II and m. The etiology of CHF was mainly idiopathic dilated cardiomyopathy and ischemic heart disease. After a 4-week placebo run-in period with digoxin and diuretics, patients were randomized to receive additional ramipril or placebo. To assess heart rate variability (HRV) and arrhythmias, 24-hour ECGs were recorded at the end of the placebo run-in period, 8 and 24 weeks afterrandomization. Spectral analysis of HRV was performed during one diurnal and one nocturnal 5-minute time period. No statistically significant differences in HRV within low-, high-, and total-frequency bands were induced by ramipril in either the diurnal or nocturnal periods, both at 8 and 24 weeks after randomization. Ramipril produced a significant decrease in nonsustained ventricular tachycardia at 24 weeks of treatment (p = 0.01). These results run against previous observations showing an increase in parasympathetic tone with ACE inhibitors in heart failure. The present study thus suggests that the effects of ACE inhibitors in CHF are variable and depend on the patient and concomitant treatment that might influence HRV such as digoxin treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 20:56:33