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Titolo:
TACHYKININ-INDUCED ACTIVATION OF NONSPECIFIC CATION CONDUCTANCE VIA NK3 NEUROKININ RECEPTORS IN GUINEA-PIG INTRACARDIAC NEURONS
Autore:
HARDWICK JC; MAWE GM; PARSONS RL;
Indirizzi:
UNIV VERMONT,DEPT ANAT & NEUROBIOL,GIVEN BLDG BURLINGTON VT 05405 UNIV VERMONT,DEPT ANAT & NEUROBIOL BURLINGTON VT 05405
Titolo Testata:
Journal of physiology
fascicolo: 1, volume: 504, anno: 1997,
pagine: 65 - 74
SICI:
0022-3751(1997)504:1<65:TAONCC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS-CERULEUS NEURONS; SUBSTANCE-P; SENSORY NEURONS; INWARD CURRENT; RAT-BRAIN; GANGLION; CHANNELS; ANTAGONIST; MODULATION; SLICES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Hardwick et al., "TACHYKININ-INDUCED ACTIVATION OF NONSPECIFIC CATION CONDUCTANCE VIA NK3 NEUROKININ RECEPTORS IN GUINEA-PIG INTRACARDIAC NEURONS", Journal of physiology, 504(1), 1997, pp. 65-74

Abstract

1. Whole mount preparations from guinea-pig hearts were used to characterize the receptors and ionic mechanisms mediating the substance P (SP)-induced depolarization of parasympathetic postganglionic neurones of the cardiac ganglion. 2. Measurement of the amplitude of depolarization in response to superfusion of different tachykinin agonists (neurokinins A (NKA) and B (NKB), SP, and senktide) gave a rank order potency of NKB = senktide > NKA > SP, indicating involvement of an NK3 receptor. The use of the selective tachykinin receptor antagonists SR 140333, SR48986, and SR 142801 demonstrated that only the NK3 receptor antagonist XR 142801 inhibited the XP-induced depolarization. 3. The SP-induced depolarization was not inhibited by Ba2+, TEA, or niflumic acid, or altered by reduced Cl- solutions, but was attenuated in reduced Na+ solutions. Single electrode voltage clamp studies demonstrated thatthe SP-induced inward current increased in amplitude at more negativepotentials, had a reversal potential of approximately 0 mV, and was reduced in amplitude in reduced Na+ solutions. 4. We conclude that the XP-induced depolarization in guinea-pig postganglionic parasympatheticneurones of the cardiac ganglion is due to NK3-mediated activation ofa nonselective cation conductance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 10:34:22