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Titolo:
NITRIC-OXIDE INHALATION REDUCES PULMONARY TIDAL VOLUME DURING EXERCISE IN SEVERE CHRONIC HEART-FAILURE
Autore:
BOCCHI EA; AULER JO; GUIMARAES GV; CARMONA MJ; WAJNGARTEN M; BELLOTTI G; PILEGGI F;
Indirizzi:
RUA OSCAR FREIRE,NUMERO 2077,APTO 161 BR-05409011 SAO PAULO BRAZIL UNIV SAO PAULO,SCH MED,INST HEART SAO PAULO BRAZIL
Titolo Testata:
The American heart journal
fascicolo: 4, volume: 134, anno: 1997,
pagine: 737 - 744
SICI:
0002-8703(1997)134:4<737:NIRPTV>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR-FUNCTION; RELAXING FACTOR; GAS-EXCHANGE; HYPERTENSION; DISEASE; MECHANISMS; FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Bocchi et al., "NITRIC-OXIDE INHALATION REDUCES PULMONARY TIDAL VOLUME DURING EXERCISE IN SEVERE CHRONIC HEART-FAILURE", The American heart journal, 134(4), 1997, pp. 737-744

Abstract

Multiple mechanisms have been proposed to explain the hyperventilation and the limited exercise capacity in congestive heart failure (CHF) including increased intrapulmonary pressures, total pulmonary resistance, and airway abnormalities. We investigated the hypothesis that inhalation of nitric oxide could influence the maximum exercise capacity and excessive ventilatory response to exercise in CHF. Fifteen patientsin CHF (mean age 48 +/- 12 years) underwent a control and a nitric oxide inhalation progressive treadmill exercise test with 30 ppm. We determined the maximum oxygen consumptiom (peak VO2), CO2 production (VCO2), minute pulmonary ventilation (VE), respiratory rate, tidal volume (VT), ventilatory equivalent for oxygen (VE/VO2), ventilatory equivalent for carbon dioxide (VE/VCO2), estimated physiologic dead space/tidal volume ratio (VD/VT), VE/VCO2 slope, heart rate, systemic arterial pressure, VE/exercise time slope, and VT/exercise time slope during every incremental exercise. Mean maximum exercise values of heart rate, systolic systemic arterial pressure, diastolic systemic arterial pressure, VD/VT, respiratory rate, peak VO2, VO2/heart rate, VE/CO2, and maximum exercise time were unchanged by inhalation of nitric oxide. Therewas a strong trend toward reduction of VE/VO2 from 53 +/- 15 to 47 +/- 12 (p = 0.051) and in maximum VE from 58 +/- 21 to 48 +/- 17 L x min(-1) (p = 0.059). Maximum VT decreased from 1639 +/- 556 to 1406 +/- 479 ml (p = 0.04). The VE/VCO2 slope was reduced from 43 +/- 12 to 35 +/- 8 (p = 0.018). Two patients had signs of pulmonary congestion during peak exercise or the recovery period with inhalation of nitric oxide. The VE/exercise time slope and VT/exercise time slope during incremental exercise were reduced by inhalation of nitric oxide, demonstrating a statistically significant minor increase in VE and VT. Inhalation of nitric oxide attenuated the excessive increase in VT response to exercise in CHF. The L-arginine-nitric oxide pathway may be involved in mechanisms contributing to hyperventilation during exercise in CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:55:12