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Titolo:
AXONAL CYTOSKELETAL PATHOLOGY IN AGED AND DIABETIC HUMAN SYMPATHETIC AUTONOMIC GANGLIA
Autore:
SCHMIDT RE; BEAUDET LN; PLURAD SB; DORSEY DA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,BOX 8118,660 S EUCLID AVE ST LOUIS MO 63110
Titolo Testata:
Brain research
fascicolo: 2, volume: 769, anno: 1997,
pagine: 375 - 383
SICI:
0006-8993(1997)769:2<375:ACPIAA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; INTERMEDIATE FILAMENT PROTEIN; MOTOR-NEURON DISEASE; IMMUNOHISTOCHEMICAL CHARACTERIZATION; NEUROFILAMENT PROTEINS; NEUROAXONAL DYSTROPHY; PERIPHERIN; NEUROPATHY; PHOSPHORYLATION; SWELLINGS;
Keywords:
NEUROAXONAL DYSTROPHY; SYMPATHETIC GANGLIA; NEUROFILAMENT; PERIPHERIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Schmidt et al., "AXONAL CYTOSKELETAL PATHOLOGY IN AGED AND DIABETIC HUMAN SYMPATHETIC AUTONOMIC GANGLIA", Brain research, 769(2), 1997, pp. 375-383

Abstract

Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and MF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistentwith the terminal axonal and/or synaptic origin of neuritic dystrophyin the sympathetic ganglia of aged and diabetic human subjects. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 15:52:59