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Titolo:
MECHANISMS OF CALCIUM SIGNALING BY CYCLIC ADP-RIBOSE AND NAADP
Autore:
LEE HC;
Indirizzi:
UNIV MINNESOTA,DEPT PHYSIOL MINNEAPOLIS MN 55455
Titolo Testata:
Physiological reviews
fascicolo: 4, volume: 77, anno: 1997,
pagine: 1133 - 1164
SICI:
0031-9333(1997)77:4<1133:MOCSBC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEA-URCHIN EGGS; ADENINE-DINUCLEOTIDE PHOSPHATE; INDUCED CA2+ RELEASE; SURFACE ANTIGEN CD38; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; TRANSMEMBRANE GLYCOPROTEIN CD38; ADENOSINE-DIPHOSPHATE-RIBOSE; PANCREATIC BETA-CELLS; LEUKEMIC HL-60 CELLS; TRANS-RETINOIC ACID;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
188
Recensione:
Indirizzi per estratti:
Citazione:
H.C. Lee, "MECHANISMS OF CALCIUM SIGNALING BY CYCLIC ADP-RIBOSE AND NAADP", Physiological reviews, 77(4), 1997, pp. 1133-1164

Abstract

Cells possess various mechanisms for transducing external signals to intracellular responses. The discovery of inositol 1,4,5-trisphosphate(IP3) as a messenger for mobilizing internal Ca2+ stores has centralized Ca2+ mobilization among signaling mechanisms. Results reviewed in this article establish that, in addition to IP3, the internal Ca2+ stores can be mobilized by at least two other molecules, cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), via totally independent mechanisms. Cyclic ADP-ribose is a newly discovered cyclic nucleotide derived from NAD, but, unlike adenosine 3',5'-cyclic monophosphate, its main signaling function is modulation of Ca2+-induced Ca2+ release, a major mechanism of Ca2+ mobilization in addition to the IP3 pathway. Evidence shows that cADPR may in fact be responsible for mediating the Ca2+-mobilizing activity of the gaseous messenger nitric oxide. Cells responsive to cADPR are widespread and include species from plant to mammal, indicating the generality of cADPR as a signaling molecule. In addition to cADPR, NAADP, a metabolite of NADP, can also mobilize Ca2+ stores. The release mechanism and the storeson which NAADP acts are distinct from cADPR and IP3. Nicotinic acid adenine dinucleotide phosphate may play a role in generating Ca2+ oscillations, since liberation of NAADP in live cells by photolyzing its caged analog produces long-lasting Ca2+ oscillations. These two new Ca2agonists are intimately related, since the same metabolic enzymes can, under appropriate conditions, synthesize either one, suggesting a unified mechanism may regulate both pathways. Elucidation of these two new Ca2+ mobilization pathways is likely to have an important impact onour understanding of cellular signaling mechanisms.

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Documento generato il 24/11/20 alle ore 08:35:47