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Titolo:
LOSS OF ALPHA-V INTEGRIN EXPRESSION AND RECURRENCE IN NODE-NEGATIVE LUNG-CARCINOMA
Autore:
SMYTHE WR; WASFI D; BAVARIA JE; ALBELDA SM; KAISER LR;
Indirizzi:
UNIV PENN,MED CTR,THORAC ONCOL RES LAB,3400 SPRUCE ST PHILADELPHIA PA19104 UNIV PENN,MED CTR,DEPT SURG,DIV CARDIOTHORAC SURG PHILADELPHIA PA 19104 UNIV PENN,MED CTR,DEPT MED,DIV PULM & CRIT CARE MED PHILADELPHIA PA 19104
Titolo Testata:
The Annals of thoracic surgery
fascicolo: 4, volume: 64, anno: 1997,
pagine: 949 - 953
SICI:
0003-4975(1997)64:4<949:LOAIEA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR PROGRESSION; CELL ATTACHMENT; HUMAN-MELANOMA; BREAST-CANCER; ALPHA(V)BETA(3); RESECTION; RECEPTOR; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
W.R. Smythe et al., "LOSS OF ALPHA-V INTEGRIN EXPRESSION AND RECURRENCE IN NODE-NEGATIVE LUNG-CARCINOMA", The Annals of thoracic surgery, 64(4), 1997, pp. 949-953

Abstract

Background. Despite ''curative'' resection, metastases develop in many patients with node-negative (NO) nonsmall cell lung carcinoma. Alternative biologic markers for this tumor would be useful. Integrins are cell adhesion molecules that are thought to be important in tumor progression, and expression of these molecules previously has been shown to be altered in non-small cell lung carcinoma. We evaluated alterations in integrin expression and clinical outcome. Methods. Immunohistochemical staining of tumor specimens was performed, and clinical data were reviewed retrospectively. Results. Data were complete for 42 patients. Half of all patients (21/42) and 9 of 26 patients with negative nodes experienced tumor recurrence during follow-up. Neither histologic type nor tumor differentiation status correlated with recurrence. However, loss of the alpha v integrin subunit was associated significantly with recurrence in the NO group. Seventy-five percent of patients withnegative nodes who exhibited recurrence lost alpha v expression, compared with only 10% of patients with negative nodes who did not exhibitrecurrence (p = .0.012). Alterations of other integrin subunits did not correlate significantly with prognostic follow-up variables. Conclusions. Loss of alpha v expression may serve as a marker for patients with node-negative non-small cell lung carcinoma who are at high risk for recurrence, potentially directing additional therapies. (C) 1997 byThe Society of Thoracic Surgeons.

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Documento generato il 30/09/20 alle ore 04:02:25