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Titolo:
MECHANISM OF INHIBITION OF NA-GLUCOSE COTRANSPORT IN THE CHRONICALLY INFLAMED RABBIT ILEUM()
Autore:
SUNDARAM U; WISEL S; RAJENDREN VM; WEST AB;
Indirizzi:
OHIO STATE UNIV,SCH MED,DIV GASTROENTEROL,DEPT MED,N-214 DOAN HALL,410 W TENTH AVE COLUMBUS OH 43210 OHIO STATE UNIV,SCH MED,DIV GASTROENTEROL,DEPT PHYSIOL COLUMBUS OH 43210 YALE UNIV,SCH MED,DEPT MED NEW HAVEN CT 06320 UNIV TEXAS,DEPT PATHOL GALVESTON TX 77555
Titolo Testata:
American journal of physiology: Gastrointestinal and liver physiology
fascicolo: 4, volume: 36, anno: 1997,
pagine: 913 - 919
SICI:
0193-1857(1997)36:4<913:MOIONC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ILEAL BRUSH-BORDER; CRYPT-VILLUS AXIS; TRANSMISSIBLE GASTROENTERITIS; CHLORIDE TRANSPORT; SODIUM; ABSORPTION; EXCHANGE; ELECTROLYTES; MEMBRANES; DISEASE;
Keywords:
GLUCOSE ABSORPTION; SODIUM ABSORPTION; ELECTROLYTE TRANSPORT; CHRONIC INTESTINAL INFLAMMATION; SODIUM-GLUCOSE COTRANSPORT; SODIUM-POTASSIUM-ADENOSINE-TRIPHOSPHATASE; INFLAMMATORY BOWEL DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
U. Sundaram et al., "MECHANISM OF INHIBITION OF NA-GLUCOSE COTRANSPORT IN THE CHRONICALLY INFLAMED RABBIT ILEUM()", American journal of physiology: Gastrointestinal and liver physiology, 36(4), 1997, pp. 913-919

Abstract

In a rabbit model of chronic ileal inflammation, we previously demonstrated that coupled NaCl absorption was reduced because of an inhibition of Cl-/HCO3- but not Na+/H+ exchange on the brush-border membrane (BBM) of villus cells. In this study we determined the alterations in Na+-stimulated glucose [Na+-O-methyl-D-glucose (Na+-OMG)] absorption during chronic ileitis. Na+-OMG uptake was reduced in villus cells from the chronically inflamed ileum. Na+-K+-adenosinetriphosphatase (ATPase), which provides the favorable Naf gradient for this cotransporter inintact cells, was found to be reduced also. However, in villus cell BBM vesicles from the inflamed ileum Na+-OMG uptake was reduced as well, suggesting an effect at the level of the cotransporter itself. Kinetic studies demonstrated that Na+-OMG uptake in the inflamed ileum was inhibited by a decrease in the maximal rate of uptake for OMG without a change in the affinity. Analysis of steady-state mRNb and immunoreactive protein levels of this cotransporter demonstrates reduced expression. Thus Na+-glucose cotransport was inhibited in the chronically inflamed ileum, and the inhibition was secondary to a decrease in the number of cotransporters and not solely secondary to an inhibition of Na+-K+-ATPase or altered affinity for glucose.

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Documento generato il 27/09/20 alle ore 00:49:30