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Titolo:
DYNAMIC AND STATIC MRT USING THE SUPERPARAMAGNETIC MRT CONTRAST-MEDIUM RESOVIST(R) FOR VISUALIZING PRIMARY AND SECONDARY LIVER-TUMORS
Autore:
VOGL TJ; SCHWARZ W; HAMMERSTINGL R; KUMMEL S; BALZER JO; MACK MG; DIEBOLD T; BALZER T; SHAMSI K; BECHSTEIN WO; SCHREM H; NEUHAUS P; FELIX R;
Indirizzi:
HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,STRAHLEN & POLIKLIN,AUGUSTENBURGER PL 1 D-13353 BERLIN GERMANY HUMBOLDT UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,CHIRURG KLIN D-13353 BERLIN GERMANY SCHERING AG,KONTRASTMITTEL D-1000 BERLIN GERMANY
Titolo Testata:
RoFo. Fortschritte auf dem Gebiete der Rontgenstrahlen und der neuenbildgebenden Verfahren
fascicolo: 3, volume: 167, anno: 1997,
pagine: 264 - 273
SICI:
0936-6652(1997)167:3<264:DASMUT>2.0.ZU;2-P
Fonte:
ISI
Lingua:
GER
Soggetto:
IRON-OXIDE; CLINICAL-APPLICATION; LESIONS; TUMORS; AGENT; PARTICLES; EFFICACY; SPLEEN;
Keywords:
MAGNETIC RESONANCE IMAGING; LIVER; CONTRAST MATERIAL; LIVER TUMOR; SUPERPARAMAGNETIC IRON OXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
T.J. Vogl et al., "DYNAMIC AND STATIC MRT USING THE SUPERPARAMAGNETIC MRT CONTRAST-MEDIUM RESOVIST(R) FOR VISUALIZING PRIMARY AND SECONDARY LIVER-TUMORS", RoFo. Fortschritte auf dem Gebiete der Rontgenstrahlen und der neuenbildgebenden Verfahren, 167(3), 1997, pp. 264-273

Abstract

Purpose: To analyse characteristics of benign and malignant liver tumours in dynamic and static MR imaging with the superparamagnetic MR contrast medium Resovist(R). Material and methods: All 30 patients were examined on a 1.5 Tesla MR unit (Magnetom 63 SP, Siemens AG, Erlangen,Germany) using proton density (PD) weighted (w), T-2-weighted-spin-echo, a T-1-weighted SE, and a T-1-weighted FLASH-2D gradient echo (GRE)sequence before, during and after the application of Resovist(R). Dynamic imaging was performed using a T-2-weighted GRE-sequence (TurboFLASH; T-R/T-E = 11/30; flip angle = 10 degrees; T-1 = 600 ms). Histopathology revealed benign liver lesions in 8 patients and malignant lesions in 22 patients. Results: Dynamic T-2-weighted sequence revealed an early loss of signal intensity in normal liver parenchyma (percentage signal intensity loss (PSIL) = 40.0 +/- 12.2% by 4 mu mol Fe/kg, 47.2 +/- 18.8% by 8 mu mol Fe/kg and 62.7 +/- 13.0% by 16 mu mol Fe/kg), in the spleen, as well as in FNH (PSIL = 49.5 +/- 7.3% by 8 mu mol Fe/kg), and regenerating nodules in the first minute after application of Resovist(R). In two of 4 cases with HCC a short drop in signal intensitywas immediately observed after the application, whereas signal intensity remained unchanged in all other malignant liver tumours. Enhanced PDw and T-2-weighted SE-sequences revealed an improved detection and delineation of malignant liver lesions versus plain MR imaging. 17 liver lesions of a size lower 10 mm were additionally detected in postcontrast T-2-weighted SE-sequences in 4 patients. Conclusion: Dynamic and static versus plain MR imaging of primary and secondary liver lesions is markedly improved by the superparamagnetic contrast material Resovist(R), especially in case of intravenous bolus application of this liver-specific contrast medium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:16:10