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Titolo:
[I-123] IBZM SPECT IN PATIENTS TREATED WITH TYPICAL AND ATYPICAL NEUROLEPTICS - RELATIONSHIP TO DRUG PLASMA-LEVELS AND EXTRAPYRAMIDAL SIDE-EFFECTS
Autore:
SCHLOSSER R; SCHLEGEL S; HIEMKE C; NICKEL O; BOCKISCH A; RAO ML; HAHN K;
Indirizzi:
UNIV MAINZ,DEPT PSYCHIAT,UNTERE ZAHLBACHER STR 8 D-55131 MAINZ GERMANY UNIV MAINZ,DEPT NUCL MED D-6500 MAINZ GERMANY UNIV BONN,DEPT PSYCHIAT D-5300 BONN GERMANY
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 2, volume: 75, anno: 1997,
pagine: 103 - 114
SICI:
0925-4927(1997)75:2<103:[ISIPT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
D2-DOPAMINE RECEPTOR OCCUPANCY; PHOTON-EMISSION TOMOGRAPHY; SCHIZOPHRENIC-PATIENTS; I-123 IBZM; DOPAMINE; CLOZAPINE; BLOCKADE; D-2;
Keywords:
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; DOPAMINE; ANTIPSYCHOTICS; CLOZAPINE; HALOPERIDOL; BENPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
R. Schlosser et al., "[I-123] IBZM SPECT IN PATIENTS TREATED WITH TYPICAL AND ATYPICAL NEUROLEPTICS - RELATIONSHIP TO DRUG PLASMA-LEVELS AND EXTRAPYRAMIDAL SIDE-EFFECTS", PSYCHIATRY RESEARCH-NEUROIMAGING, 75(2), 1997, pp. 103-114

Abstract

[I-123]Iodobenzamide (IBZM) is an iodine-labeled dopamine receptor ligand and can be used to visualize brain D-2 receptors in humans with single photon emission computerized tomography (SPECT). The ratio of striatal IBZM uptake to uptake in frontal cortex (ST/FC ratio) represents a semiquantitative measure of D, receptor binding in the striatum. Our study sample included six patients treated with haloperidol (3.0-8.0 mg/day orally; one patient with an average of 0.9 mg/day intramuscularly), five patients with benperidol (9.0-15.0 mg/day orally) and ninepatients treated with clozapine (200.0-600.0 mg/day orally). Typical neuroleptics (TNs) and atypical neuroleptics (ANs) were significantly different in their ST/FC ratios. The ST/FC ratios indicated that patients treated with benperidol exhibited the lowest ST/FC ratios, with increasingly higher ratios in patients on haloperidol or clozapine. We found a curvilinear relationship between the ST/FC ratios and the dose/kg body wt. of TNs and ANs on the basis of a dose-normalization according to K-i-values of the neuroleptic at D-2 receptors and a weaker, but also curvilinear relationship between ST/FC ratios and normalized dosages according to clinically defined chlorpromazine equivalents. The specific uptake of IBZM did not correlate with the plasma levels of the TN haloperidol at the present dose range (0-12.4 ng/ml). For clozapine, a meaningful negative correlation between plasma levels and ST/FC ratio could be established. There was a negative continuous correlation between uptake of IBZM and extrapyramidal side effects, which is different from the threshold-based relationship between extrapyramidal side effects and IBZM uptake reported previously. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:31:25