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Titolo:
EFFECT OF GLICENTIN, OXYNTOMODULIN AND RELATED PEPTIDES ON ISOLATED GASTRIC SMOOTH-MUSCLE CELLS
Autore:
RODIER G; MAGOUS R; MOCHIZUKI T; MARTINEZ J; LENGUYEN D; BALI JP; BATAILLE D; JARROUSSE C;
Indirizzi:
CHU ARNAUD VILLENEUVE,INSERM U376 ENDOCRINOL PEPTIDES & REGULAT GEN,371 RUE DOYEN GASTON GIRAUD F-34295 MONTPELLIER 5 FRANCE FAC PHARM MONTPELLIER,CNRS EP 612 F-34060 MONTPELLIER FRANCE SHIZUOKA COLL PHARM,BIOORGAN CHEM LAB SHIZUOKA 422 JAPAN FAC PHARM MONTPELLIER,CNRS URA 1845 CHIM & PHARMACOL F-34060 MONTPELLIER FRANCE
Titolo Testata:
Pflugers Archiv
fascicolo: 6, volume: 434, anno: 1997,
pagine: 729 - 734
SICI:
0031-6768(1997)434:6<729:EOGOAR>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE IMMUNOREACTIVITY; ACID SECRETION; GASTROINTESTINAL-TRACT; TACHYKININ RECEPTORS; MOLECULAR-FORMS; CONSCIOUS RAT; CHOLECYSTOKININ; RABBIT; ENTEROGLUCAGON; PANCREAS;
Keywords:
SMOOTH MUSCLE; ANTRUM; GLICENTIN; OXYNTOMODULIN; C-TERMINAL FRAGMENTS; PROGLUCAGON; STOMACH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
G. Rodier et al., "EFFECT OF GLICENTIN, OXYNTOMODULIN AND RELATED PEPTIDES ON ISOLATED GASTRIC SMOOTH-MUSCLE CELLS", Pflugers Archiv, 434(6), 1997, pp. 729-734

Abstract

Glicentin (proglucagon 1-69 GLIC) and oxyntomodulin (proglucagon 33-69 or OXM) are two peptide hormones that are co-released from ileum andlarge intestine during digestion. They modulate in vivo gastric acid secretion and the gastro-pyloro-duodenal activity. The specificity of their effects is linked to the presence of their C-terminal octapepide. As yet, no isolated target cell that responds specifically to this family of peptides has been described. The present report describes thein vitro effect of human synthetic GLIC, OXM and octapeptide-bearing fragments on smooth muscle cells isolated from the rabbit antrum. GLICor OXM decreased the mean length of the cells by: 13.9 +/- 0.8% and 15.5 +/- 0.9%, respectively - GLIC being 16 times more potent than OXM (respective EC50 values: 5 and 83 pM). The C-terminal fragments OXM(19-37) and OXM(30-37) were as efficient as GLIC or OXM. Their potencies were OXM = OXM(19-37)much greater than OXM(30-37). Glucagon, which corresponds to OXM without the C-terminal octapeptide, or glucagon-like peptide-1 (7-36 amide) did not have any effect. The response to OXM wasnot influenced by antagonists to muscarinic, cholecystokinin or substance P receptors. In conclusion, our studies demonstrate for the firsttime an isolated target cell that responds specifically to GLIC, OXM and other octapeptide-bearing peptides.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:10:15