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Titolo:
EFFECTS OF SELECTIVE ACTIVATION OF DOPAMINE D-2 AND D-3 RECEPTORS ON PROLACTIN SECRETION AND THE ACTIVITY OF TUBEROINFUNDIBULAR DOPAMINE NEURONS
Autore:
DURHAM RA; EATON MJ; MOORE KE; LOOKINGLAND KJ;
Indirizzi:
MICHIGAN STATE UNIV,DEPT PHARMACOL & TOXICOL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT PHARMACOL & TOXICOL E LANSING MI 48824 UNIV CENT CARIBE,DEPT BIOCHEM BAYAMON PR 00960
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 335, anno: 1997,
pagine: 37 - 42
SICI:
0014-2999(1997)335:1<37:EOSAOD>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN; MEDIAN-EMINENCE; AGONIST; QUINELORANE; D2; ACCUMULATION; POTENT; INDEX; ACID;
Keywords:
DOPAMINE RECEPTOR AGONIST; PNU-95,666; PD128907; DOPAC (3,4-DIHYDROXYPHENYLAL ACETIC ACID); MEDIAN EMINENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.A. Durham et al., "EFFECTS OF SELECTIVE ACTIVATION OF DOPAMINE D-2 AND D-3 RECEPTORS ON PROLACTIN SECRETION AND THE ACTIVITY OF TUBEROINFUNDIBULAR DOPAMINE NEURONS", European journal of pharmacology, 335(1), 1997, pp. 37-42

Abstract

Dopamine agonists with activity at both dopamine D-2 and D-3 receptorsubtypes stimulate tuberoinfundibular dopamine neurons and inhibit prolactin secretion from the anterior pituitary. The purpose of the present study was to identify the dopamine receptor subtypes mediating these effects using recently developed selective agonists for dopamine D-2 (PNU-95,666) and D-3 (PD128907) receptors. The activity of tuberoinfundibular dopamine neurons was estimated by measuring either the synthesis (accumulation of 3,4-dihydroxyphenylalanine [DOPA] following inhibition of decarboxylase activity) or metabolism (3,4-dihydroxyphenylacetic acid [DOPAC] concentrations) of dopamine in the median eminence, the region of the hypothalamus containing axon terminals of these neurons. In one experiment, the activity of mesolimbic dopamine neurons was also determined by measuring DOPA accumulation in terminals of theseneurons in the nucleus accumbens. Activation of dopamine D-2 receptors with PNU-95,666 caused dose-and time-related increases in DOPAC concentrations in median eminence which were temporally correlated with decreases in plasma prolactin concentrations. Activation of dopamine D-3receptors with PD128907 decreased DOPA concentrations in the nucleus accumbens, but had no effect on concentrations of DOPAC or DOPA in themedian eminence or prolactin in plasma. These results reveal that tuberoinfundibular dopamine neurons are regulated by dopamine D-2 rather than D-3 receptors, and suggest that the ability of mixed dopamine D-2/D-3 receptor agonists to increase the activity of these neurons is mediated by an action at dopamine D-2 receptors. Furthermore, these results confirm that tuberoinfundibular dopamine neurons are not regulatedby inhibitory dopamine D-2 or D-3 autoreceptors. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:44:10