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Titolo:
CAPSAICIN-INDUCED NITRIC-OXIDE-DEPENDENT RELAXATION IN ISOLATED DOG URETHRA
Autore:
NISHIZAWA S; IGAWA Y; OKADA N; OHHASHI T;
Indirizzi:
SHINSHU UNIV,SCH MED,DEPT UROL,3-1-1 ASAHI MATSUMOTO NAGANO 390 JAPAN SHINSHU UNIV,SCH MED,DEPT PHYSIOL 1 MATSUMOTO NAGANO 390 JAPAN
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 335, anno: 1997,
pagine: 211 - 219
SICI:
0014-2999(1997)335:2-3<211:CNRIID>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOWER URINARY-TRACT; GENE-RELATED PEPTIDE; SMOOTH-MUSCLE CELLS; NADPH-DIAPHORASE; AFFERENT NEURONS; SENSORY NEURONS; RAT; SYNTHASE; INHIBITION; BLADDER;
Keywords:
CAPSAICIN; URETHRA, DOG; NITRIC OXIDE (NO); SMOOTH MUSCLE RELAXATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Nishizawa et al., "CAPSAICIN-INDUCED NITRIC-OXIDE-DEPENDENT RELAXATION IN ISOLATED DOG URETHRA", European journal of pharmacology, 335(2-3), 1997, pp. 211-219

Abstract

Capsaicin (5 x 10(-8) to 5 x 10(-5) M) produced a non-adrenergic and non-cholinergic phasic relaxation in a concentration-dependent manner in isolated dog urethral preparations precontracted by noradrenaline. The mode of action of capsaicin was investigated with special reference to the possible involvement of endogenous nitric oxide (NO). A marked tachyphylaxis was observed in the responses to capsaicin. Pretreatment with N-G-nitro-L-arginine-methyl-ester (L-NAME) prevented or markedly reduced the inhibitory effect of L-NAME. Methylene blue inhibited the capsaicin-induced relaxation. In preparations stored at 4 degrees Cfor 72 h, the reduction in the capsaicin-induced relaxation was significantly greater than that in the relaxation induced by either electrical field stimulation or by sodium nitroprusside. We conclude that capsaicin produces an endogenous-NO-dependent relaxation in the isolated dog urethra via mechanisms that deteriorate during cold storage of thepreparations. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 08:43:38